ID   A0A3P8P5H4_ASTCA        Unreviewed;       299 AA.
AC   A0A3P8P5H4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Artemin-like {ECO:0000313|Ensembl:ENSACLP00000012272.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012272.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000012272.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000012272.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000256|ARBA:ARBA00009832}.
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DR   AlphaFoldDB; A0A3P8P5H4; -.
DR   STRING; 8154.ENSACLP00000012272; -.
DR   Ensembl; ENSACLT00000012572.1; ENSACLP00000012272.1; ENSACLG00000008380.1.
DR   GeneTree; ENSGT00950000182993; -.
DR   OMA; STWHALY; -.
DR   OrthoDB; 4316464at2759; -.
DR   Proteomes; UP000265100; Chromosome 18.
DR   Bgee; ENSACLG00000008380; Expressed in anal fin.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173:SF9; ARTEMIN; 1.
DR   PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}.
FT   DOMAIN          184..298
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          92..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  33824 MW;  6AFCF7787717B36C CRC64;
     MTHRSVWIAK NMSCCTQRGR RRRRRSGFPV LCGAEQDARR TAGGTRWRIR RADRQDVTSA
     KGKVLLWVLI ALLPLVEGAH MKGGAGVGSD SGHTVGLLGN QEERQLPVTL PEMVEDKEQK
     EDSDPYSTWH PLYDPFVMDE VDDHPSSRWV GRSPRSSDPT EPQPKGSSKK KKKKKEKEEE
     TETRNRKGKG RNGHPKQSSR HCRVEKKEMR VRDLGLGFDS DEIVLFKFCV GSCQAERTNY
     DLALKALLEN GSLPRRTARK VSSHPCCRPD RYEPVSFMDA KTTWRTIQSL SAASCMCMG
//