ID A0A3P8P5M2_ASTCA Unreviewed; 754 AA.
AC A0A3P8P5M2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012317.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000012317.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000012317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR AlphaFoldDB; A0A3P8P5M2; -.
DR STRING; 8154.ENSACLP00000012317; -.
DR Ensembl; ENSACLT00000012617.1; ENSACLP00000012317.1; ENSACLG00000008394.1.
DR GeneTree; ENSGT00940000158265; -.
DR OMA; TDWVHDT; -.
DR Proteomes; UP000265100; Chromosome 23.
DR Bgee; ENSACLG00000008394; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.90.1280.20; -; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002246; Cl_channel-4.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF2; H(+)_CL(-) EXCHANGE TRANSPORTER 4; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01115; CLCHANNEL4.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 62..86
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 221..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 249..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 326..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 362..379
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 509..534
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 594..658
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 691..749
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 754 AA; 84067 MW; 640B7E45558E3778 CRC64;
MNGAGNLMDF LDEPFPDVST YEDFHTIDWL REKSRDTDRH RKITSKSKES LWELIKSLLD
AWSGWVVMLL IGLLSGTLAG VIDLAVDWMT DLKEGVCLSA FWYSHEQCCW TSNETTFDDR
DKCPQWQKWA ELMTGHAEGA GAYVLNYFLY ILWALLFSFL AVSLVRVFAP YACGSGIPEI
KTILSGFIIR GYLGKWTLLI KTVTLVLAVS SGLSLGKEGP LVHVACCCGN LFCSLFSKYS
KNEGKRREVL SAAAAAGVSV AFGAPIGGVL FSLEEVSYYF PLKTLWRSFF AALVAAFTLR
SINPFGNSRL VLFYVEYHTP WYMAELVPFI LLGVFGGLWG TLFIRANIAW CRRRKTTQLG
KYPVLEVIAV TGITALLAYP NPYTRRSTSE LISELFNDCG ALESSQLCDY VNNPNMSRPV
DDIPDRPAGP GVYNALWQLT LALIFKIVIT IFTFGMKIPS GLFIPSMAVG AIAGRIVGIA
VEQMAYHHHD WIIFKNWCRP GADCVTPGLY AMVGAAACLG GVTRMTVSLV VIMFELTGGL
EYIVPLMAAA VTSKWVADAF GKEGIYESHI LLNGYPYLDV RDEFTHRTLA TDVMRPRRND
PPLAVLTQDS TTVEDVETLI KDTDYNGFPV VVSRESERLI GFVQRRDLTL AIKNARQKQD
GVVSSSVVYF TEDAPQLPAS NPQPLKLRRI LNLSPFTVTD HTPMETVVDI FRKLGLRQCL
VTRSGRLLGI ITKKDVLRHM AQMMNQDPES IMFN
//
