ID   A0A3P8P624_ASTCA        Unreviewed;       546 AA.
AC   A0A3P8P624;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protein wntless homolog {ECO:0000313|Ensembl:ENSACLP00000012444.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012444.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000012444.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000012444.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the wntless family.
CC       {ECO:0000256|ARBA:ARBA00008148}.
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DR   AlphaFoldDB; A0A3P8P624; -.
DR   Ensembl; ENSACLT00000012747.1; ENSACLP00000012444.1; ENSACLG00000008476.1.
DR   GeneTree; ENSGT00390000005897; -.
DR   Proteomes; UP000265100; Chromosome 18.
DR   Bgee; ENSACLG00000008476; Expressed in zone of skin and 8 other cell types or tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR047843; WLS-like_TM.
DR   InterPro; IPR009551; Wntless.
DR   PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR   PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR   Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          178..496
FT                   /note="Wntless-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF06664"
SQ   SEQUENCE   546 AA;  62844 MW;  C6BC830A57A4A4F8 CRC64;
     MAGAIIENMS TKKLVIVGVI LLLFQAFAFM VGGLIAPSPT TAVHYLATKC VDKPNKPQQT
     KWFMPWGRKE CDKIRSFDEA MAKRIEANNI VFAVHIPLPN KEMSPWFQFM LVILQFDIAF
     KMYNQIEDGS LVYIDVGLAY RDDMDSEWTE MAHSFEQRKL SCNFTATKTH ENEGRYYECD
     LLPFMEVGSV AHKYYLLNIR LPVNERKKIN VGIGEIRDIR LVGIHQNGGF TKVWFAMKTF
     LTPSILIIMI WYWRRITLMS RPPVLLEKVI LALGISMTFI NIPVEWFSVG FNWTWMLLFG
     DIRQGIFYSM LLSFWIIFCG EHLMDQTERN RFSIYWKQVG PVVFGSFCLF IFDMCERGVQ
     LKNPFYSIWA SDIGTELAMA FIIVAGICAC LYFLFLCFMV FQVFRNISGK RMSLPAMSKA
     RQLHYEGLIF RFKFLMLVTL ACAALTVIFF IISQVNEGHW HWGEHTVQVN SAFFTGIYGM
     WNLYVFAIMF LYAPSHKHYG DEQSSGQCIT GDGGANSGED LHLTTTITHL DGPTVVYKMT
     GKEAQE
//