ID   A0A3P8P6I0_ASTCA        Unreviewed;       723 AA.
AC   A0A3P8P6I0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=TANK binding kinase 1 {ECO:0000313|Ensembl:ENSACLP00000012600.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012600.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000012600.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000012600.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 8154.ENSACLP00000012600; -.
DR   Ensembl; ENSACLT00000012907.1; ENSACLP00000012600.1; ENSACLG00000008562.1.
DR   Ensembl; ENSACLT00000012925.1; ENSACLP00000012618.1; ENSACLG00000008562.1.
DR   GeneTree; ENSGT00950000182937; -.
DR   OMA; WSADMPV; -.
DR   OrthoDB; 2957757at2759; -.
DR   Proteomes; UP000265100; Chromosome 17.
DR   Bgee; ENSACLG00000008562; Expressed in spleen and 8 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   CDD; cd13988; STKc_TBK1; 1.
DR   CDD; cd21954; TBK1_C; 1.
DR   Gene3D; 1.20.1270.420; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR041309; TBK1_CCD1.
DR   InterPro; IPR041087; TBK1_ULD.
DR   PANTHER; PTHR22969; IKB KINASE; 1.
DR   PANTHER; PTHR22969:SF14; SERINE_THREONINE-PROTEIN KINASE TBK1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF18394; TBK1_CCD1; 1.
DR   Pfam; PF18396; TBK1_ULD; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          9..310
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   723 AA;  83332 MW;  21FE21A3607FDFB4 CRC64;
     MQSTANYLWL ISDLLGQGAT ANVYRGRHKK TGDLYAVKVF NNLSFLRPLD VQMREFEVLK
     KLNHKNIVKL FAVEEESNTR HKVLVMEYCP CGSLYTVLEE SSNAYGLPED EFLIVLHDVV
     AGMNHLREYG IVHRDIKPGN IMRVIGEDGR SVYKLTDFGA ARELEDDEQF VSLYGTEEYL
     HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITE
     KPSGTISGHQ KCENGKIEWS TEMPVSCSLS KGLQSLLTPV LANILEADQE KCWGFDQFFA
     ETNDILHRTV VYVFSLQQAT LHHVYIHEYN TAALFQELLC RRTSIPLHNQ ELLYEGRRLV
     LDANRQAKTF PKTSRENPIM LVSRESVATV GLIFEDPSPP KVQPRYDLDL DASYAKTFAG
     DVGHLWKTSE SLLLYQELVR KGVRGLIELM KEDYNEIMRK KLEVFHLCNF CTQMLEKTEQ
     LFEVLMQANM LSSEYDEISD MHKKVLRISG SLEPIERTTQ DVKSKFLPGG LLTDTWTQQV
     GTHPEDRNVE KIKVLLDAIT AIYQQFKKDK AERRLPYNEE QIHKFDKQKL VLHASKARTL
     FTDECAMKYR LFISKSEEWM RKVHHVRKQL LNLSSQLISI EKEVTMLMER AIKLQEQLPQ
     KVLPLVSSGM KPQAYLSQNT LVEMTLGMKK LKEEMEGVVK ELAENNHFLE RFGTLTLDGG
     LRG
//