ID A0A3P8P7E1_ASTCA Unreviewed; 2401 AA.
AC A0A3P8P7E1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Chondroitin sulfate proteoglycan 4-like {ECO:0000313|Ensembl:ENSACLP00000012926.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000012926.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000012926.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000012926.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR STRING; 8154.ENSACLP00000012926; -.
DR Ensembl; ENSACLT00000013245.1; ENSACLP00000012926.1; ENSACLG00000008822.1.
DR GeneTree; ENSGT00940000154091; -.
DR OMA; EELHFMV; -.
DR OrthoDB; 4072625at2759; -.
DR Proteomes; UP000265100; Chromosome 12.
DR Bgee; ENSACLG00000008822; Expressed in muscle tissue and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF12; CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..2401
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018069290"
FT TRANSMEM 2273..2296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..202
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 212..391
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 436..531
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 562..655
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 672..770
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 904..998
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1030..1122
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1138..1228
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1250..1349
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1367..1458
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1482..1572
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1589..1689
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1714..1813
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1847..1939
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 2303..2333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2306..2333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2401 AA; 269283 MW; 97A612AD95308076 CRC64;
MDSVGKNTQK KKLWLCGLLW WSLLVHLASG ASFYGDGFVQ LKARQSSDRN VLRIRFRTSS
TNGLLFLAAG QTHYFLLELH TGRLQLKLDL GSGEQMLESD RGTHLNDLAW HHVEVHHVQL
NITLTVDSNS HSSVKVPGPH YSLNTDGLYV GGSGGLDRPY LPRDPVCFRG CMDDVLFNER
DLLSSLRPYT GYKNVHEVSL GCSPQFFATE EDPISFFSSR AYISLPTWIT EQEAAFECVM
HTSAKEGIIL YNAAREEKFV ALEIQDGLLV AVVGTGETKT ELRSLTLIND RKWHSIKLYF
SSKSLELTID GEMVKSGIIP HPKALQLKGY LFVGGIDDGT RSEVKKMGLV SISGKRARGG
SFKGCLKNIA VNRVKMGLSN AVVTKDISVG CEPEKESDPP TALNPTNTPG SLFHLITPTP
SIDMSTLAWG LDRRYGFNFV QLKNLIVQEG GRASLEAKHI KVLLDFRKLG IRQSQIMFRI
EEQPLRGQIR LDVDQDQEEN TFSMLDLWHE RVMYIHGGSE EPDDFFMFSI FSSSRKQVPD
YLKGTKLYRY NISVTSTNDA PELSLPQGNL FVLLENSKKR LTTDVLMATD IDSNYTDLFF
SVLGNLNADA GYLEVESNPG KAVTSFSYID LDELRVYYVH TGVRNSRIVL RVSDGEKVSN
TVVLRIMAVA LEYKIANNTG LDIIQGETAI IGSKQLALQT NAVNQVVDIR YDVIEPPQYG
ELQRLHSSGE WRHTDSFSQR LLEKERLRYV STFQDIQTSN PTDYFKCKVN VAARETTEIL
FPITVKWVKY HLVRNTMIDL DKVRKVTLNS ECLFATTEGV TLSEDDLYFR VLTTPKKGKL
LLNTIVLKKN STFSQRDVTD LKVHYELVDR PYQDTTDRFK FHLVSKHAQS QNYDFQFSIK
ADVNSVFIRN AGLSLQEGES KLITKDELFA ETLSTKDMFY TVINSPKHGK LVRISQSNSN
ASYDNILTFS NKDILEERII YVHDDSETTQ DEFTFIASTT QGFKPFIAED EPGSKESVFN
ISIQLLNDQK PVRVIDKVFH VVRDGQKLLT TEDLQYQDAD SDFDDGQLVY TRRGIPMGDL
VLVNDTTYRL FQFRQKDLEE KRVLFIHKGV SSGRFVLFVS DGKHFVSGLL HISAHDPFLK
VDNNTGLLVQ KGHSVVFSTS NYSVMSNLDI RDDKEVIFKL DDGPKHGSLY RNETTVVTFT
QADLKAGLIR YQHNDSKYLT DYFNITVKAK SLQLTSRVNV KVYLESHQRP PIVQHHDTLL
VEEGKPAKID ETKLEVTHED NLPSEIVFTV KVAPSYGFLR RFVEAEERYI GTKQSPVNTF
TQNDINSGNI QYVQVEPNKV NDTFILDATN GVTDVTNIKM FVDIIPLLIP LQVSNITLNE
GAAKALTQDV LKVTNRHFSG INFFYNLTQP PQHGHIEHSR HPGVAITTFT RRQVEHEFIY
YVHDSSETLA DNFTLVANDT SLRKQSAAQM VHIQVIPAND EPPVIITNRV LRVWVSSVTE
ITLDDLSVQD QDTPPEELHF MVTPPSNGHL ALKSAPMKAV LNFTQAHIDQ GQLVFVHKGA
MSGGFNFQAN DGVNFTPRQI FSITAKALAL SLEKSQPLKV FPGSSRPITN EYLQAVTNDM
SNTSNRVITF SVTRHPKLGR LVMRQPNNST ADISTFTQDM VDRKEVFYIQ TPVESVGWEA
MDSMTFSVAS PPASVDSLTF RFDISYENTG PEHNTILLAN TGAEVTEGES VIIDESKLDA
TNLMSKLPTP QRSSYEVWFQ VTSLPQHGVI VVGERNLTKE KPNFSQFIIK KYGITYKHDN
SETTQDSFIF SAWLNPKGKT AQRPEDDSDV VVEHFNITVI PVNDQPPLLK TKAPSLKVVQ
GDTIALGPEN LKIEDLDNPP DDIKFSVISK PSNGYLALKG SLNESIVAFT QAQINNRSVC
FVHDGSSVSG AFYFSVTDGY HKPIYKLFNL EVSEITITLV KNTGLELQQG RTLVSLTEDN
LAAETNGKNV TVYYQITRPL RFGKLLRDNR EVTLFDQEDL QTGRLSYHMI SLSSVEDSFE
FTAFTSEANL TDQVLNITVK PLLQTGKGLR IPNGITVKFN VNFLNASELA NISDSDPVFE
VLSHPRYGKV VRPKLKMTIK AIPVESFTFQ EIMQAKVALE LNANMTGVEE LNDSVVFVLK
ADSVQPAKGE LHFTVVPYDP AFFPPTKSPV SATSSVPQAS IKTAFPVLST VFLSSQQPSI
NQQKFRGRNR WGNSNRTSVF GTTLGKPSQT EEFLFKNTPV RVESYPQKTS NPLLIILPLL
ALLLLVIIFV VLVVFLRHHR QRKQSTATAQ EQTSTGLPNS SSYQGQTQRS PAVPTVTVTP
LNHNCPGSPV LDRLLTPNQG TTYNAIDSNM VVSSWSNGSP VTSCQMIRTA TPTLQKNQYW
V
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