ID A0A3P8P7Z5_ASTCA Unreviewed; 1490 AA.
AC A0A3P8P7Z5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tensin-2-like {ECO:0000313|Ensembl:ENSACLP00000013138.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000013138.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000013138.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000013138.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR STRING; 8154.ENSACLP00000013138; -.
DR Ensembl; ENSACLT00000013464.1; ENSACLP00000013138.1; ENSACLG00000008981.1.
DR GeneTree; ENSGT00940000163886; -.
DR OMA; CYHRRAG; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000008981; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR CDD; cd01213; PTB_tensin; 1.
DR CDD; cd09927; SH2_Tensin_like; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035012; Tensin-like_SH2.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR033929; Tensin_PTB.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF1; TENSIN-2; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 78..250
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 255..381
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1217..1326
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1490 AA; 164488 MW; FD2116A70E956BCC CRC64;
MGCIHSTSTV GIQKHAHDTE TGGIPVKADP EVPPEILQLA EVTPSCTSTP EVHTSTKSTS
QKKRGSIPRS KSVEQVMEHV MERHYDFDLT YITERIISVF FLPDLEEQQY RRNLQEVASM
LKSKHQDKFL LLNLSEKRHD ITRLYPKVQD YAWPDLHAPP LDRICAVCKA METWLTSDPN
NVVVLHCKGN KGKTGVIVAA YMHYSKITAG ADQALTTLAM RKFCEDKVSS SLQSSQKRYI
YYFGGLLSGT IKMNSSPLFL HQILIPSLPN FQAGGGFYPF LKIYQSLQLV YTSGVYDPQS
SRARKLCVTM EPALLLKGDI MVKCYHWRRR ATEREVVFRV QFHTCTVHGA QLWFGKSELD
QACIDDRFPP DATVEFIFAN GPEKIKGQEY HQNDTSIKVE YNTSDPVVRW DSYENFNLHH
EDSMENIFHT RGPLDGSLYA QVRKRRGPGA TASPASTNGC LTTSPTVKTQ TSTQSKTLTY
TSNSSYSSVP SDHLADTALS INERDNIDYP LRRSNREDET KEKTRGKERD RETAILDDTD
PLGPGGLRRE HLCCGQASIK CGDMGLERDR EPCLPNSHCL GRCKSIKNHP KSQTLPVLPS
KSVSPHPHSA HMELCHRHSV HPLPELPWER STPPLPLPFV HRPCYPYSTR DHAHPHSHTL
PASNRLCTGE ECHLLHYSSH IPASHLSNQP QPSSPYREMF FGSPAQSSGC PWQDCSCRRE
HHSASLKTIH SAYPDQSETI HWSQGTGVPP QWETENPWDI AREAEFWQCK SNTPVFHLYQ
PSLDRGPNLE HPRFVVAPHQ NYPIPQSLID IRDGASSGYH TPLQPRHSCP CSPYESSPAE
SHESRGYASG YHSGSASPLP ANSPSPAKGK LPETPLGSRD QMHNEHRKVE KAKTDTEDEI
SQHSETKSDS NGQSSTPGPD SDHDYTLIGS SSPTHTEDSV NVDSPSQSQD TSTPEESSAS
NKNVKPTETQ TQGSIIPVNP VQTSGESSES SSPDGKLGAV KVTGHAHGSN TSHASSYATV
IITPVQVQLN GSALPNDSPS DSSRGVSINP ATSLSSSPST TFPNSPIGSP ELQSSPLRSS
SATDTAGQSL TPDRNSSADT KPPSPVPDGY HTPNFPSASY YYSLLNVPHV PYTGYTAVTI
PTIQPPLPEK KRFSTTAGSL NGHNSLIRAS SAPSPTHHVT FSPAVGEQRR GSAQHSCREE
PDIRVNAKFV QDSSKYWYKP GITRDQAIAV LKDKEPGSFL IRDSNSFQGA YGLALKVATP
PPNANFSWSK GDPLEQLVRH FLIESGPRGV KIKGCQNESY FGSLSALVYQ HSITPISLPC
PLHIPEKDLV GELQEMQSAT NTSTAAELLK QGAACNVLYL NSVETESLTG PEAVSKATKF
TLSLNPRPVA TMVHFKVSSQ GITLTDSKRR LFFRRHYPIN SITFSSLDPH DQRWTNSDST
SSKMFGFVAR RTGTATENVC HLFAEMDPEQ PAVAIVNFIN KVMLGPQLRR
//
