ID   A0A3P8P856_ASTCA        Unreviewed;       845 AA.
AC   A0A3P8P856;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=RAP1 GTPase activating protein 2a {ECO:0000313|Ensembl:ENSACLP00000013197.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000013197.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000013197.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000013197.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8P856; -.
DR   Ensembl; ENSACLT00000013526.1; ENSACLP00000013197.1; ENSACLG00000009035.1.
DR   GeneTree; ENSGT00940000165230; -.
DR   Proteomes; UP000265100; Chromosome 14.
DR   Bgee; ENSACLG00000009035; Expressed in spleen and 7 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        33..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          371..587
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          240..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          807..845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..678
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..738
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..777
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        807..825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  92693 MW;  C6B10D7107BDE784 CRC64;
     MENPGNNSYP FPTTISLILW SILSAFAKTN ICLNFIFSSS FSSAFLFIYI FLYLFLIRLE
     EIGCSPLHGN AVSHSCTHCR CLSSHNSALP CALSLRPLPI CALPLPSPSL SLSLLVSLSL
     SHMHTHIHST SPLVHWSPAN AAPSTDCEMF SPACKGSAGE PRKQELLNIS NVPLGECPPS
     PPRTAPPSMK SAEFFDMLEK MQDDYIPYPR IEDVLEKGGP YPQVILPQFG GYWIEDVEAP
     AGTPSSSESS FCEEEDGGEG MSPGGGHSYR LECNSTARAY RKHFLGKEHM NYYCTSSSIG
     NLIMSLKHEE AEGQEFLRIM LRSRTKTVHD RISLAGINQL PSVPQIAKVF CDDATGLKFN
     PVLYPRGSQL IVAYDEHEVN NTFKFGVIYQ KFGQTSEEEL FGNNEETPAF KEFLSILGDT
     VELQDFKGFR GGLDVSHGQT GSESVYTVFR QREIMFHVST KLPFTEGDVQ QLQRKRHIGN
     DIVAIVFQEE PTPFVPDMIA SNFLHAYVLV QAENPCTEHT TYKVSVTARE DVPSFGPPLP
     NPAIFKKGPE FRDFLLTKLI NAENACYKSD KFAKLEGRTR AALLDNLHDE LHRQSQSALG
     LGQVGEEDKL ENGGHGGLLE SFKRAMRVRS HSMETMVGSH RHRSPGVGGG VPASLSGGGL
     PQSTSECTKS TFTPPVLSAK SPLKSPVKRR SGLFPRLHSS TETSSDKHTR GDQKFAESCL
     LSQDVKSETS SNPSSPEICP NKERPFVKLK ECGGGRQNIS RSSSSTSSFS STTGETEALE
     ELEMASHPPI ASSSAFSPAL NIESQGSCTP VIMCRSPTDG KTKTSPRSNL KFRFDKMSHS
     STTSE
//