ID A0A3P8P8N8_ASTCA Unreviewed; 951 AA.
AC A0A3P8P8N8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SLIT-ROBO Rho GTPase-activating protein 3-like {ECO:0000313|Ensembl:ENSACLP00000013345.1};
GN Name=ARHGAP4 {ECO:0000313|Ensembl:ENSACLP00000013345.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000013345.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000013345.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000013345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8P8N8; -.
DR STRING; 8154.ENSACLP00000013345; -.
DR Ensembl; ENSACLT00000013674.1; ENSACLP00000013345.1; ENSACLG00000009145.1.
DR GeneTree; ENSGT00950000182824; -.
DR OMA; ECAGARG; -.
DR OrthoDB; 2904755at2759; -.
DR Proteomes; UP000265100; Chromosome 20.
DR Bgee; ENSACLG00000009145; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07656; F-BAR_srGAP; 1.
DR CDD; cd11956; SH3_srGAP4; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035678; srGAP4_SH3.
DR PANTHER; PTHR14166:SF16; RHO GTPASE-ACTIVATING PROTEIN 4; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 23..304
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 490..676
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 715..774
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..46
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 794..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 106667 MW; CF409E6FD0AD284C CRC64;
MMTSHGKLRR EKGSLAEYES QMKDLRAQLT DQIKILDSQV EVKQQQLSDL SEFLRRRGDI
ESEYARALDK LTERFTHKTK KKEQWGQSVC QVWSVLLTQT RLESREHAAL GDTCCNTLTQ
RLAHGTEDTH RLHKRSKEVG IQMQDELLKV TTELQTALKT YNQYHTDCLI AEGKLKEAER
LEERHTGKSA ELGPGQLGGQ RRSSVKKMER LMEKRHGRVQ ETQLKCTKAR NDYLLNLAGA
NAAMNKYYLQ DVSTLIDCCD LGFHLSVERV MKCYLASRWR IQKTEETGLK QLETAVTSLD
QSGDRDALLQ QHDAAFCLPF RFNYHPHEGD QVCEVSAESQ VRYELETRFQ QLQSRLAAVT
LETEEISKTL KATLAALLDT MCDSDCNPSP DVPSNLSHEP PGGGTLPKLT LAKRRANQQE
TETYYFTKVK EFLTSSSLAS KLQAKHDILQ DAIQKAEAVD SDPSRMQCAR SVRVRKSRPV
SQFCHTLFNT DILSYIESSG QQIPVVVESC IRFINLHGLH HEGIFRVPGS QREVNLLRDA
FERGEDPLSD SECDLDSVAG VLKLYFRGLE PPLFPYDSYT QLLECVQIEE EVDKAVQIKM
IVSTFPRPLL IVMRYLFAFL NHVSQYSDEN MMQPYNLAVC FGPSLLRGMD SDDAVARQPQ
VNDLVKTMIL QHDSIFPSQS ELPGPVYEKH MTLEQEYCEP ITEEGDGETE HLPSEDEWEA
VAMFDYVARS PAELSFKQGE PLILHSKASS DWWRGEVGGV KGLIPHKYIS VLEGSDRGKR
EEGGGGGGGG STGNLTAEDP QTENTTRMRV NSDSASLPGR QRGSEGSPSR KPPTSPATRH
LPVSQERRHT LDTLRQGNFR PPDRPPFIQA ERTPIDKEMI NRQMNSVFKE LLSRQPPLQG
SGITAPVATA APAPSSSSSS LSTSSSVPQA APVAKKAGFG LRGRALFRPV D
//
