ID A0A3P8P8Z1_ASTCA Unreviewed; 660 AA.
AC A0A3P8P8Z1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Spectrin repeat containing, nuclear envelope 2b {ECO:0000313|Ensembl:ENSACLP00000013467.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000013467.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000013467.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000013467.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR AlphaFoldDB; A0A3P8P8Z1; -.
DR Ensembl; ENSACLT00000013799.1; ENSACLP00000013467.1; ENSACLG00000009174.1.
DR GeneTree; ENSGT00940000154656; -.
DR Proteomes; UP000265100; Chromosome 19.
DR Bgee; ENSACLG00000009174; Expressed in zone of skin and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 3.
DR InterPro; IPR026696; AKAP6/CEP68.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR14514:SF4; NESPRIN-2; 1.
DR PANTHER; PTHR14514; PKA ANCHORING PROTEIN; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..609
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 631..660
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 601..660
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 344..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 76839 MW; D18D762410D41356 CRC64;
RVRKLKETLV TVQQLDKNMS NLRTWLSRIE TELAKPVVYS TCHSDEIQRK LAEQQDLQRD
IEQHTESVAS VLTLCDVLLH DADACGSDSE NDSIQQTTLS LDRRWRNICA MSMERRMIEE
TWRLWCKFLD DYSRFEHWLK TAEMTAASPD SADVLYTSAK EELKKFEAFQ RQVHERLTQL
ELVNKQYRRL ARENRTDAAS KLKVMVHEGN QRWDSLQRRV AAVLRRLKYF TSQREDFEGT
REGILVWLTE MDLQLTNVEH FSESDIEEKM RELNLQGFQQ EITLNTNKID ALIVFGENLI
QKSAPLDAVL IEDELEELHS YCQEVFGRVA RFHHRLVNRR PVLEEEEREM SDRDTDRDDS
PDLTPSWMAE RRRKEVMCHL LVPPIERSGR ETPLSVDSIP LEWDHTVDVG GSSSHEDDED
ATFFSALSGV IERWELLQAH KNAADIKQDL EQWQKLNSDL SDVTSWLGRV LPELERLKRI
EMQKIFNSYK CLMISINLSS RHFLRGDSTE LHEQQEALDS ANHSWTQACS GLESWERSLH
SAVMQCQELR GRQRRVSSLQ AISSQLLLEA TGEDSVEAKE KVHVISNKLH LLLRQVAADL
RPLFYRVLRA AFPLHLLFFM LLVLACLVPL SEENYSCTLT NNFARSFYPM LHYTNGPPPT
//
