ID A0A3P8P9Z2_ASTCA Unreviewed; 1759 AA.
AC A0A3P8P9Z2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSACLP00000013828.1};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSACLP00000013828.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000013828.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000013828.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000013828.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSACLT00000014164.1; ENSACLP00000013828.1; ENSACLG00000009369.1.
DR GeneTree; ENSGT00940000155279; -.
DR OMA; WISRRCA; -.
DR Proteomes; UP000265100; Chromosome 3.
DR Bgee; ENSACLG00000009369; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 4.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 69..101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 102..134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 135..167
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 168..191
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 238..270
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 304..336
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 337..369
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 370..402
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 403..435
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 436..468
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 469..501
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 502..534
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 535..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 568..600
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 601..633
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 634..666
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 667..699
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 700..732
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 733..765
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 766..798
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 968..1156
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1158..1282
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1473..1556
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1449..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1586..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1451..1470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1759 AA; 193249 MW; E83D1D5A657A627A CRC64;
MALKLIVRCY VVIENSGRSF FDASQCPKKN LCMTSDSNTS FLRAARAGNV DKVLEYLKGG
VDISTCNQNG LNALHLAAKE GHIDLVQELL DRGAAVDSAT KKGNTALHIS SLAGQADVVK
ILSKRGADIN AQSQNGFTPL YMAAQENHLD VVRYLLENGG NQSIATEDGF TPLAIALQQG
HNQVVSVLLE NDTKGKVRLP ALHIAARKDD TKSAALLLQN DHNADVQSKM MVNRTTESGF
TPLHIAAHYG NVNVATLLLN RGAAVDFTAR NGITPLHVAS KRGNTNMVRL LLDRGSQIDA
KTRDGLTPLH CAARSGHDTA VELLLERGAP LLARTKNGLS PLHMAAQGDH IECVKHLLQH
KAPVDDVTLD YLTALHVAAH CGHYRVTKLL LDKRANPNAR ALNGFTPLHI ACKKNRVKVM
ELLVKYGASI QAITESGLTP IHVAAFMGHL NIVLLLLQNG ASADVSNIRG ETALHMAARA
GQVEVVRCLL RNGAMVDARA REEQTPLHIA SRLGKTEIVQ LLLQHMAHPD AATTNGYTPL
HISAREGQVE TASVLLEAGA SHSLATKKGF TPLHVAAKYG SLDVAKLLLQ RRAPPDSAGK
NGLTSLHVAA HYDNQNVALL LLDKGASPHT MAKNGYTPLH IAAKKNQMEI ATVLLRYGAE
TNILTKQGVT PLHLASQEGH ADMAALLITK GAQINVPTKS GLTALHLAAQ EDKVAVAEIL
ARNGANLDQQ TKLGYTPLIV ACHYGNAKMV NFLLQNGASV NAKTKNGYTP LHQAAQQGNT
HIINVLLQYG AKPNATTVNG NTALGIARRL GYISVVDTLR VVTEEIITTT TTVTEKHKLN
VPETMTEVLD VSDEEGDDTM TGDGGEYLRP EDLRELGDDS LPGQYLDGMN YLRFSLEGGR
TDSSDRSFTP THHSYYSSKH EGMMEEMFVS FQVSSLARET ERDSYRLSWG TENLDNVALS
SSPVHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCSA PTRVTCRLVK RHRLATMPPM
VEGEGLASRL IEVGPSGAQF LGKLHLPSAP PPLNEGESLV TRILQLGPPG TRFLGPVIVE
IPHFAALRGK ERELVILRSE TGESWKEHHC EHTQEELNQI LNGMDEELET PEELERKRIC
RIITRDFPQY FAVVSRIKQD SNLIGPEGGI LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP
VSIDVVRKLL GNKASFSPIV TLEPRRRKFH KPITMTIPVP KSNSDPVLNG FGGDTPTLRL
LCSITAETRL HILTFHVTHQ LAPNPLLISR FWLIDCRQVQ ESVNFSTQVY REIICVPYMA
KFVIFAKTHD PIEARLRCFC MTDDKIDKTL EQQENFAEVA RSRDVEVLEG KPIYADCFGN
LVPLTKSGQH HLFSFYAFKE NRLALFIKIR DNTQEPCGRL SFMKEPRNYR SLAQNAICNL
NITLPSYCKE SDSDQEQEEE VKAANPQDEA ERKEQRLAII ADHLGFSWTE LAQELDFSEE
RINEIRTGNP NSLQDQSHAL LKVWTEREGN LATATLIKRL TKINRMDIVH LIESRTSEEE
TSHTYAEIEW TIAQDHSEGF AALHEDMDSP RISKRTEAAK KSPRSGQQVP IVSAEDLSSS
LSSLHETTGR PVTDSTAAGL LRTVHKDKPQ KEMETTQCEP TASVLCLLQA DNLPDIPLQT
LTEEKYIDED GNMVVKKVTR KVIRKYVSPD GMETQEVTIE GSHQESVQIE EGDAVSKVVK
RTVLHSGGDQ KEVRASDVC
//
