ID A0A3P8PAG6_ASTCA Unreviewed; 2410 AA.
AC A0A3P8PAG6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000014008.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000014008.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000014008.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8154.ENSACLP00000014008; -.
DR Ensembl; ENSACLT00000014345.1; ENSACLP00000014008.1; ENSACLG00000009573.1.
DR GeneTree; ENSGT00940000164851; -.
DR OMA; TPFNNTT; -.
DR Proteomes; UP000265100; Chromosome 9.
DR Bgee; ENSACLG00000009573; Expressed in zone of skin.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF264; ADHESION G-PROTEIN COUPLED RECEPTOR G2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2060..2083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2095..2116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2122..2144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2164..2186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2214..2242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2263..2285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2291..2313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2058..2314
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1691..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2410 AA; 259039 MW; 396054D10D1B902E CRC64;
MVILEMSGPI NVCSLKKLLQ QIIASNNLFT AESSLTRLMV CGAPDLPVQR LLESNLTWVA
SDLRSSDVCQ PDPTRLACEA SETLAVLLTD SCPSDTSAVP TTTELSTLAN GITAAMQSLT
DTTKSLTNTS GDVYATIENT VQKKENTTFF QTTASAKSPL AQPILQNSSQ IVPSTVVNKT
TVQNTLPNET QLTNTITSTF IAVHNTTTVM PDSVLKSTTL SKITNASTPS PNQTVHKATT
TATSPDLTTI YNVTTATAYA KDYTTKNNVV AVTPFPTDNV TSPGLATVTP SPSGTTVYNV
TTTGAFTPTG KHTFVSNVTA SDSNDTTGTL NNVYNVTTES KNKAVYNSSE SSVSSTTMYI
SNAVAYNKTE TSNINTTAYN SVVSGNNYNT TTAKNNSTTV YSETTAGYSY RENVTKANNT
TTVNNNYTTV SPFLTSLNNR TPYNSITSGT SDRETGNSYN ATTASNIYAT TYNSAMSDNN
YNTTTASNNS TTLYNTAMSN NNFTTAYNAT TARNNYTTVN SATLTGDSHT TYNTTTAGDS
YSTAYNQTTT SKNGSTAYNA TIAGSNYTTV YSETTADNSY TVHSANTSAK NSTTAYNTTT
ANNNYPTVSP FLTTLNSTTV YNSVTSDNNA ITVRNNYTTV NSATTTGDNY TTYNTTIAAD
SYPTAYTQTT TSKNDSTVYN ATVAGSDYTT VYSETTAGNS YIETGNIYNT TTASNNYTTD
NYTTVLSANT RAKNSTTAYN TTTANNNNTT VSPFLTTLSN TSLYNSITSG NNDRQTGNSY
NTTTANNNST TLYNTAMLSN NFTTAYNATT ANNNNTTMSP FLTTLNNTTV YNSFTSGTND
RQPGNSYNTA TANNNSTTVH SATTERNNYT TVDGTTTAGN NYKIPPTTDS NNYTTAHNAT
TASNIYATTY NSAMSDNNYN TTTAINNSTT VSPFLTTLNS TTVYNSVTSD NNAITVRNNY
TTVNSATTLS LYNSITSGNN DRQTGNSYNT TTANNNSTTL YNTAMLSNNF TTAYNATTAR
NNYTTVNSAT TTGDTYTTYN TTIAADSHPT AYTQTTSSKN DSTVYNATVA GRNYTTVYSE
TTAGNSYIET GNIYNTTTAS NNYTTVSPFL TTPNSTTVYN SITSGNNDRE TDNNYNTTTT
NISSTTVYNT AVSNNNYTTV YNATMSDNNY NTTTAINNST TLYNTDMSSN NLTTAHNAAT
VRNNYTTVNS ATTTDDNYTT YNTTIAADSY PTVYTQTTTS KNDSTVYNAT IDGSNYTTMY
SETTAGNSYI ETGNIYNTTT ANNNYTTVSP FLTTLNNTSL YNSFTSGNND RQTSNSYNTT
TANNNSTASN IYATTYNSAM SENNYNTTTA SNNSTTLYNT AMSSNNFTTA YNATTVRNND
RQPGNSYNAT TANNNSTTVH SATIERNNYT TVDGTTTAGN NYIIPQNTTS GSNNYTTTGG
HSYTKVYDAT TVNNNDTVVH NATTSGTNLN ENTTNQNYTT LNYTTTPGSN STLVSSNFST
ATTMNSSTAT TPGNNYTAMY NASTAVINYT VVYNAITSGN NFNVTATNNN YTIVYNATGS
GSNYTLVYAA TTADNNYTAM YNVTTAGTTL HNGVATTSNT TVSTTTISPN YTMIKSTTTA
SNNYTTPVII TPTILSQNKT TAIIGTTEKS TTAAVSHSTK PTSAPLKNQT ANFTTVSLTH
VTTISKNETM STTAASTVQT DDRPEAGLTT TTTTTTTTTT TTENASVVII SPATTATTIT
GHGPQDLNGT TAEVSLTYTT PLTKTTTTTT VAENTGTSTT DVQTTDEAVY LLNQTQAISL
LNASQVSVLV ETLEKHLDSP SVSPSVVIKV VSNLMDSNPE ALSKSANRLI HLVDDLGVKL
AVTGGDGILS TSSLVVAVKT VNGSNFTTIL FDVFNTDHVQ FSGPKRTMKS SEPALASVYL
PASLTSGISP EEQKQANSVQ FTFYAKNSFF KDASLDNKTL VSAVLGSSVA NLSISNLSEN
IKFTIRNRNP VHENYTAKCA FWDFTLNSGG GGWSSVGCFV VNSTPEYTIC SCSHLTSFAV
LLDLSRQELP DQKNTQILTF ITYIGCGISA IFLAITLLTY LSFPKLLRDI PAKILVQLCL
SLLFLNLVFL LDSWLASHNN TGLCICTAFF LHYFLLTSFT WAGLEALHMY LSIVRVFTPY
LSQYMLKFTL TGWGIPLVIV IIVISVDKNN YGLINYGKHT NDTSDNFCWL SNNIAFYVGV
VAYFLLIFIL CLLAFIVVMG QLSRIKKQNP HNQSPKRSVM TDLRSVTGLV IILGLTWGFA
LFAWGPLYLP FVYLFSIFNS LQGFFVFVFH CAIKENVRRQ WRTYLCCGKL RLAENSDWSR
TFTQNKKNIS RSSAITLDPK FTSRSSSVVS CGTNSSGSVF ADSGISDSSN NDVVLNEIHR
GNLKQGKTTK
//
