ID   A0A3P8PAM4_ASTCA        Unreviewed;       683 AA.
AC   A0A3P8PAM4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000014076.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000014076.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000014076.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR   STRING; 8154.ENSACLP00000014063; -.
DR   Ensembl; ENSACLT00000014404.1; ENSACLP00000014063.1; ENSACLG00000009611.1.
DR   Ensembl; ENSACLT00000014418.1; ENSACLP00000014076.1; ENSACLG00000009611.1.
DR   GeneTree; ENSGT00940000164714; -.
DR   OMA; HHLEYMT; -.
DR   OrthoDB; 3084493at2759; -.
DR   Proteomes; UP000265100; Chromosome 20.
DR   Bgee; ENSACLG00000009611; Expressed in brain and 4 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   CDD; cd11509; SLC6sbd_CT1; 1.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR   PANTHER; PTHR11616:SF126; TRANSPORTER; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SNF-like; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Symport {ECO:0000256|RuleBase:RU003732};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003732};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT   TRANSMEM        83..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        113..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        452..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        497..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        527..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        573..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        612..633
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          42..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  75010 MW;  BA581E434D85C5EA CRC64;
     MSPELEENSQ GEISVPQLDA GILSEEEGSA SARPLVPVPG VGSGCDDGGG GGPTQTQDDT
     AAGNGSVTVP AAERETWTRQ MDFIMSCVGF AVGLGNVWRF PYLCYKNGGG VFLIPYLLIV
     FIGGIPVFFL EIALGQFMKQ GGVSAWNIAP LFKGLGLASM VIVFFCNTYY IMILVWGLYF
     LFHSFTNPLP WATCGHPWNT PNCTQDFRRT CHNRSTAQPA LPSSAATNSS LFSSASPLNL
     SSAQLLLNGS CMDAEGLRSP VIEFWERKVL RLSGGLHEPG DISYEMVLCL IATWIIVYFC
     MWKGVKSTGK VVYFTALFPY LVLVVLLAHG VTLPGALDGI VYYLKPDWSK LGEAQVWIDA
     GTQIFFSYAI GLGALTALGS YNRFHNNCYQ DAFVLALINS GTSFFAGFVV FSVLGFMATE
     QGVDISKVAE SGPGLAFIAY PKAVTLMPLA PLWAALFFFM LLILGLDSQF VGVEGLITGI
     MDMLPPKSAL GSLRREVVAA ICCIICFLID MSMVTEGGMY VFQLFDYYSA SGITLLWQAF
     WECVVVAWVY GADRFMDDVA RMIGYQPLPY MKWCWSYITP FVCVGVFLFH VVNYKPLTYN
     TVYTYPIWGE ALGWALALSS MLCIPVTVLY KLLRCKGSLR ERWQHLTTPV WGRHHLEYLA
     PESEAKLLPP AGTKGTLLFE SVI
//