ID A0A3P8PAR8_ASTCA Unreviewed; 818 AA.
AC A0A3P8PAR8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Toll-like receptor 1 {ECO:0000313|Ensembl:ENSACLP00000014111.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000014111.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000014111.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000014111.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8PAR8; -.
DR STRING; 8154.ENSACLP00000014111; -.
DR Ensembl; ENSACLT00000014454.1; ENSACLP00000014111.1; ENSACLG00000009636.1.
DR GeneTree; ENSGT00940000162201; -.
DR OMA; YKIFSNM; -.
DR OrthoDB; 21383at2759; -.
DR Proteomes; UP000265100; Chromosome 2.
DR Bgee; ENSACLG00000009636; Expressed in spleen and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..818
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018276480"
FT TRANSMEM 589..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 646..789
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 818 AA; 92821 MW; 26ACD3F8DC042569 CRC64;
MRVTAAVLWT AAVLVGLQKS TSSPDNFVDR SSQNLSSVPT DLPQTTEFLD LSRNYIRQLH
NGDFQKTTHL RFLNVSWNNL EEIDPQTFLD TPLLEHLDLS HNNLKNLSGQ QYLLHTVNLL
VLNLAFNRFL TMTLGSEFSS LVKLERLTVG AKNISVGDFK NIAKMKLRTL TLLLEDGLYY
EAGSLEDVHA QRLQIAFGHN PKIDRNLTAD ALSLFAEVEM MNMINGYKDL SKQLRETVKI
HTTSFYLTNI TIKWQDLTEY VNVALNTTLK HVRVSEMNVK NPPHYTTEVI KTSQVISFTA
SQAVVTSFQF SQEALYNFFI SMPVESVAIT DAPMIHMTCP KSQSPIRQLD FSFGAMSDSI
FSSAVGKNVV ECQNLRNLKN LTLVGNSLKK LELLSQRFRY MSSLQHLDLS VNSIGYDQSS
QCIWPASITN INLSSNSLTE SVFQCLPNGT QILDLQNNQI SVVPQSIFKL RNLSTLNLNA
NRLRDLPGCG TFPTLHKLLL RSNSLHAPSV NILESCPELH ILDVSFNPFT CTCTLRGFIK
LATNSEKNNN NQSGIELLNW PQGYYCTYPE DVRNSTLRDI SIPEVSCSIG LLVVAILVPA
GTLIISIVIL CHCLDVPWYM GMIWQWTRAK HRARLQQARP EDLVGLEFHA FVSYSQHDVD
WVRNSLLPNL EGPAGGLRIC HHEKHFVPGK TIIENIISCV EKCRRSVFVL SAHFVKSEWC
HYELYFATHQ RLTLGSDSIV LVLLEPLPQY LIPSKYYQLK SMMNRHTYLE WPQDRAKQRL
FWANLRAALQ TDLPNAPVTQ VQEHWAEERL EEGHRLKG
//
