ID A0A3P8PBV7_ASTCA Unreviewed; 425 AA.
AC A0A3P8PBV7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Brachyury protein homolog A-like {ECO:0000313|Ensembl:ENSACLP00000014498.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000014498.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000014498.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000014498.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; A0A3P8PBV7; -.
DR STRING; 8154.ENSACLP00000014498; -.
DR Ensembl; ENSACLT00000014846.1; ENSACLP00000014498.1; ENSACLG00000009866.1.
DR GeneTree; ENSGT00940000166269; -.
DR OMA; NEEAWRY; -.
DR Proteomes; UP000265100; Chromosome 22.
DR Bgee; ENSACLG00000009866; Expressed in ovary.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR GO; GO:0072045; P:convergent extension involved in nephron morphogenesis; IEA:Ensembl.
DR GO; GO:0035462; P:determination of left/right asymmetry in diencephalon; IEA:Ensembl.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0070121; P:Kupffer's vesicle development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
DR GO; GO:0060034; P:notochord cell differentiation; IEA:Ensembl.
DR GO; GO:0014028; P:notochord formation; IEA:Ensembl.
DR GO; GO:0031016; P:pancreas development; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0035775; P:pronephric glomerulus morphogenesis; IEA:Ensembl.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0042663; P:regulation of endodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0001757; P:somite specification; IEA:Ensembl.
DR GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
DR GO; GO:0060063; P:Spemann organizer formation at the embryonic shield; IEA:Ensembl.
DR CDD; cd20192; T-box_TBXT_TBX19-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF169; T-BOX TRANSCRIPTION FACTOR T-A; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 45..218
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
SQ SEQUENCE 425 AA; 46334 MW; 233D8C47FB776B49 CRC64;
KPQTQTQKSG KNKPRLEHLL SAVESEFQKG SEKGDASERD IKLTLEDADL WNKFKELTNE
MIVTKTGRRM FPVLRASVTG LDPNAMYSVL LDFVAADNNR WKYVNGEWVP GGKPEPQSPS
CVYIHPDSPN FGAHWMKAPV SFSKVKLSNK LNGGGQIMLN SLHKYEPRIH IVKVGGIQKM
ISSQSFPETQ FIAVTAYQNE EITALKIKHN PFAKAFLDAK ERSDHKEVSD HSTDSQQSGY
SQLGGWFIPG QSPICPSSSP PQFSSTTGHS SGSYCERYSS LRSHRAAPYP SHYPHRTTNN
YMDNTSGTLP THDSWSALQI PNSTGMGTLS HTTNSTSNSS QYPSLWSVAG TTLTPSGSAS
GSIPGGLTSQ FLRGSSYTGL TSSLPVSSPS PMYDPSLGEV GVGEAQFESS IARLTASWTP
VAQTY
//
