ID A0A3P8PD84_ASTCA Unreviewed; 1890 AA.
AC A0A3P8PD84;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Plexin A1 {ECO:0000313|Ensembl:ENSACLP00000014975.1};
GN Name=PLXNA1 {ECO:0000313|Ensembl:ENSACLP00000014975.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000014975.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000014975.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000014975.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 8154.ENSACLP00000014975; -.
DR Ensembl; ENSACLT00000015328.1; ENSACLP00000014975.1; ENSACLG00000010182.1.
DR GeneTree; ENSGT01050000244850; -.
DR OMA; HIWTLLL; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000010182; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF35; PLEXIN-A1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1890
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018061027"
FT TRANSMEM 1237..1261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..507
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1258..1307
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1890 AA; 211399 MW; 09D26EA2952FB875 CRC64;
MCHLARSVAS SGQGNFLLIG LLVIMSSSLS GGQPPPFKRF IPADCSLTHL AIHNKTGEVY
VGAVNRIFKL SRNLTNLRSH MTGPVVDNEK CYPPPSVQSC NHELAQTPNV NKLLLIDYAQ
NRLIACGSTS QGICQFLRLD DLFKLGEPHH RKEHYLSSVA ESGTMSGVII SSPQSPTSKL
FIGTPIDGKS EYFPTLSSRK LMENEENADM FSFVYQDEFV SSQLKIPSDT LSKFPAFDIY
YVYSFSSEQF VYYLTMQLDT QLTSPDASGE QFFTSKIVRL CMDDPKFYSY VEFPIGCTKD
GVEYRLVQDA FLARPGRQLA NSLGISENED ILFTVFSQGQ KNRAKPPKES ALCLFTLRKI
KKKIKERIQS CYRGDGKLSL PWLLNKELAC INSPLQIDDN FCGQDFNQPL GGTSTIEGIP
LFIDKDDGMT SVAAYDYRGN TVAFVGSRNG KLKKILVNSI NASRPAVLYE KVTVSEGGSP
LLRDMLFSPD QQYIYTLTDR QVVRVPVESC EQYTTCGECL GSRDPHCGWC VLHNVCSRKD
HCERAGEPQR FASDQRQCVE LTVQPRNISV TMSEVQLVLQ ARNVPDLSAG VNCSFEDYVE
TEGQIQGGHI FCLSPSARDI APITRNKGDK RVVKLYLKSK ETGKKFASVD FVFYNCSVHQ
SCLSCVNGSF PCHWCKYRHM CTQNANDCSF QEGRVNNSED CPQILPSTQI YIPVGVTKPI
TLAAKNLPQP QSGQRNYECV FHIQGEIHNV PALRFNSTSI QCQKTAYNYE GNDISDLPVD
LSVVWNGNFV IDNPYNIKAH LYKCYALRDS CGMCLKANPR FECGWCVGEK KCSLRQECTP
PESTWMHATT GNSRCAHPKI TKLYPETGPR QGGTMLTITG ENLGLQFKDI QNGVRIGKVA
CNPQEDEYIS AEQIVCRLND ATGYRVQEAQ VEVCVRDCSH PDYKTVSSKA FTFVSPYFSR
VHPSTGPLSG GTRITIDGSH LNAGSAVSVK IGLHPCRFER RSAKEIVCVT PAGQATGQTP
VMVDINAAEL RNPEVKFSYT EDPTILKIEP DWSIASGGTK LTITGTNLAT IKEPKMRAKY
GAAKSENNCT VLNNTVMVCL APSVAGSDKG FSDVGSSPDE IGFVMDDVRS LLVVNETFSY
HPDPVFEPLS PTGMLELKPS SPLILKGRNL IPAAPGNAKL NYTVLIGETP CILTLSESQL
LCEWPNLTGE HKVTVRVGGF EYSPGTLQIY SDSLLTLPAI IGIGGGGGLL LLVIIVVLIA
YKRKSRDADR TLKRLQLQMD NLESRVALEC KEAFAELQTD IHELTQELDG AGIPFLDYRT
YAMRVLFPGI EDHPVLKEME VPANVEKALT LFGQLLTKKH FLLTFIRTLE AQRSFSMRDR
GNVASLIMTA LQGEMEYATG VLKQLLSDLI DKNLESKNHP KLLLRRTESV AEKMLTNWFT
FLLYKFLKEC AGEPLFMLYC AMKQQMEKGP IDAITGEARY SLSEDKLIRQ QIDYKTLTLH
CVNPENENAP EVTVKSLNCD TVTQVKEKLL DAVYKGTPYS QRPKASDMDL EWRQGRMARI
ILQDEDVTTK IDNDWKRLNT LAHYQVTDGS VIALVPKQNS AYNISNSSTF TKSLSRYESM
LRTASSPDSL RSRTPMITPD LESGTKLWHL VKNHDHSDQR EGDRGSKMVS EIYLTRLLAT
KGTLQKFVDD LFETIFSTAH RGSALPLAIK YMFDFLDEQA DKHSISDPDV RHTWKSNCLP
LRFWVNVIKN PQFVFDIHKN SITDACLSVV AQTFMDSCST SEHKLGKDSP SNKLLYAKDI
PNYKNWVERY YSDISRMPAI SDQDMSAYLA EQSRLHANQF NSMSALHEIY SYIIKYKDEI
LSALERDEQA RRQRLRSKLE QVIDTMALTS
//
