ID A0A3P8PEY2_ASTCA Unreviewed; 1349 AA.
AC A0A3P8PEY2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSACLP00000015549.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSACLP00000015549.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000015549.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000015549.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000015549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSACLT00000015910.1; ENSACLP00000015549.1; ENSACLG00000010454.1.
DR GeneTree; ENSGT00940000154127; -.
DR Proteomes; UP000265100; Chromosome 5.
DR Bgee; ENSACLG00000010454; Expressed in spleen and 6 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1036..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 803..830
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1036..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 151778 MW; 2B32913F55A0AAEA CRC64;
MLRVHFTVER VAICIYFLNI EVSCFAPAFL YSRCGPDVTR RTGVLEDTTG NQSCYNGTAL
STSWLSFSFC SCFFQAVQAP CVHIYLTGTV EIGEAKAFFG RGPLASSAPA GPWGHSFYSS
FSYVSNGLHL RNSRSTLTRY NLGHSLPQVQ SVVPPAAFGV KFHKCAQVKL DTDPPQLTFF
LLVRNVGPVG GTNLSQVAIR DSISGLVPLK SEGRVVERGY QTFAIESLLA GSQVVLNYTA
HVRSQKSEVL DLPAFLTFSN ASQNDVSMFG PLRANLTLRM NSTDRIYPNH GVHFAGFVAG
FFVTMVLLLL GFLAINVIGL RTRLNLLQKR RNRSDSDPEF ADSNLSETVK DEATFEDKIV
DTMVLEDPQN MYRALENLEM SSLLHATNNL EAIRIQIYKG VMSSLLARLQ FQGQASAQAQ
ERLLSVLHGQ LLGMEGRLKE ERGARMVALA GQCNLETREE METEHCREAA EKAQAELLCQ
HADQQELLQC SVLLEKLHKL SQSQLQRILL VRHEEASAKL QRQIIEWRRV ELHKIFSEEL
EEATRMGELE KSTAKNLQHE YFTCQDQLEE VLDVVLANLR YVLAERSAQR KFLVHSLHSL
NSLISDTFSS TSSNLDSWFT YIRGGSKLPA VQVDHLQEKA QKELVMLRQR LDEALKQERR
AMHCGLIKKR RELISDMVTV HKQRQKDLSN MCKGLEGGIE VGQHLHCWQN LLTAHSLELA
ELINNLDEEA AADIRKVTMR VIQGAIADIK AIQPSAAQAV LALLPPGEQD FPLQMEPGQG
SGQGASALLV GQERLHQEGK AALRILSSTR EALKEDMEKE LQEQKALRTR CKDFFRCLCL
SQLTLSEDDR LKMKLEFQKC LSVIDRCLVM PHAVARTKLL CALAAWRKES EKQMMNPQSK
GKTSEARQKA DTSDLQLFQK KLKDRIQLYE REKEMESSIM SKVLEEMKHE REDDLHSQAD
SLAVQMAIVH YQKAERRAKV LETCRAMLTL HSLLVQQLKE RKHLERQDMA QSIQSHSYKF
SFSEQQLQEE RTTLDSLQMS QPTIKSSKTH QDDSGVGDEN CEQETVFQLQ TDCRMGAILQ
DALYKREQVT SLMAERFHLM TAKSQSMEDL KEQMELKRLY ANCDQDLDFA SQLVKRCHVS
TEVLLEALRL LLPTLPESEL LSISDALCPK QHPPSGSAEQ EHPGCAEELN RVLPVKLRED
VVHKNMLNIP SCALDKEGLQ EKRQSLMEKL LPRSGLVLQG DTAPLLTKEK GKKNSCSKAQ
QPLYKSGLPV KEQQSDSGRE EVVDTVKEAE EHTPSASACC APGSPATGEK LFVFRDPPES
CNSVDVPNRK RKRNFLNLKK GSVAPTNLP
//