ID A0A3P8PGT0_ASTCA Unreviewed; 628 AA.
AC A0A3P8PGT0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Leucine-rich repeat-containing protein 4C-like {ECO:0000313|Ensembl:ENSACLP00000016168.1};
GN Name=LRRC4C {ECO:0000313|Ensembl:ENSACLP00000016168.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000016168.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000016168.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000016168.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
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DR AlphaFoldDB; A0A3P8PGT0; -.
DR STRING; 8154.ENSACLP00000016168; -.
DR Ensembl; ENSACLT00000016544.1; ENSACLP00000016168.1; ENSACLG00000011030.1.
DR GeneTree; ENSGT00940000157405; -.
DR OMA; NNGVTYF; -.
DR OrthoDB; 4239630at2759; -.
DR Proteomes; UP000265100; Chromosome 1.
DR Bgee; ENSACLG00000011030; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0097060; C:synaptic membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF8; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..45
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 46..628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018125147"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 355..442
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 465..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 70196 MW; 92C6AFE114803E72 CRC64;
MLNTMISSLQ RQTMRGRRLK GALSNPLFVL LLALQILVVA GLVRAQTCPS VCSCSNQFSK
VICTRRSLRD VPDGISTNTR YLNLQDNLIQ VIKVDSFKHL RHLEILQLSK NHIRSIEIGA
FNGLASLNTL ELFDNRLTTI PNGAFEYLSK LKELWLRNNP IESIPSYAFN RVPSLRRLDL
GELKRLSYIS DGAFKDLSNL RYLNLGMCNL KEIPNILPLV RLEELEMSGN QLSVIKPSSF
TGLVNLQKLW MMHAQIQTIE RNSFDDLQSL VELNLAHNNL TFLPHDLFTP LHRLERVHLH
HNPWNCNCDI LWLSWWLKET VPANTSCCAR CHTPSALKGR YIGELDHSYF QCDVPVIVEP
PSDLNVTEGM GAELKCRTSS VTSISWLTPN GSLVTHGAYK VRLSVLNDGT LNFTSVTMQD
TGTYTCMVSN TAGNISASAV LNVTSLDSSG VTYFTTVTVE TTDMMGEDSQ TPLPPFGWVS
SSTTKGTPVS TRTTERTYTI PVLDPEGEGS LDEVMKTTKI IIGCFVAITL MAAVLLVIFY
KMRKQHNQQD PDGPASSMEV ITVEEELAGV AAMERHLSLP PLEHYNHYNT YKSSYHHPPM
LSTIHSSATQ EPLLIQACSK DNVQETQI
//
