ID A0A3P8PI58_ASTCA Unreviewed; 4648 AA.
AC A0A3P8PI58;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=VWFD domain-containing protein {ECO:0000259|PROSITE:PS51233};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000016741.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000016741.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000016741.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8154.ENSACLP00000016741; -.
DR Ensembl; ENSACLT00000017149.1; ENSACLP00000016741.1; ENSACLG00000011366.1.
DR GeneTree; ENSGT00950000183155; -.
DR Proteomes; UP000265100; Chromosome 3.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd19941; TIL; 11.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR025615; TILa_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46160; ALPHA-TECTORIN-RELATED; 1.
DR PANTHER; PTHR46160:SF1; NIDO DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF08742; C8; 12.
DR Pfam; PF01826; TIL; 11.
DR Pfam; PF12714; TILa; 3.
DR Pfam; PF00094; VWD; 13.
DR SMART; SM00832; C8; 12.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 8.
DR SMART; SM00216; VWD; 11.
DR SUPFAM; SSF57567; Serine protease inhibitors; 11.
DR PROSITE; PS51233; VWFD; 13.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 82..261
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 470..641
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 844..1004
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1204..1381
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1574..1750
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1959..2122
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2325..2495
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2703..2880
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 3089..3268
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 3471..3650
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 3858..4035
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 4182..4362
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 4564..4648
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 4648 AA; 505294 MW; B184EA553C9EA463 CRC64;
MYNQDPAYLN AGRGCKTVGI YLLLFWELYS YKLGASFWSD RTCAQKCTCT STGLQCRNEP
CSFSQICKPA SFQFSCQTVP RGTCTISGDP HYYTFDNTVF HFQGTCTYVL SEQCNSGRPY
YRVEGKNEHR GSTQVSWTRL VKVHVYNDTI ELVKGRRGQA KVNGNFASTP FSLSNGTVQV
YESGFSVFVS TDFGLVVSYD TNHHVQISLP YTYQNGTCGL CGNFNGIRRD DFQTRDGEVV
SSDVVFANSW QASGDDEPGC GPQCGGLDCA VCTVEETALY SNTDHCGILS SSSGPFTACH
QQLPPQSFVD SCVYDLCVGG GYQPILCQAL TVYASQCQQS GIQLPSWRTP GFCEIPCPAN
SHFESEGTGC PPTCVNPNST HNCPLPPQES CICDSGYILS GGVCVPHAEC GCSFEGRYYR
SGQTVILDED CGRRCSCSYG SMTCHSHGCG PLESCRVEDG ERGCRPNSYE TCWIRGPGSY
QTFDGLTYQY PGACRLTLAK VMGLSSHPHF MVTAEKVPKG QQGFARILHF EAEGIHVSIE
MVNGQLIRLP FSTTSNRIQI FHSSIYSVII RTSFGVTVQT VWPHFVRVTA PGVYNGSLGG
LCGNYNGHPH DDFRTPNGVL VNSSQDFGDS WRDGSLAAHC VESMNQNSTT NYNSTEYCGI
LSSPDGPFVP CWSVVDPSQQ VDVCVEIMGA CNNPASTLCG VLRDYALMCQ QKGVALGQWR
NATGCALTCP SNSHYELCGT SCPSACPSLS FPFTCDTVCQ EGCQCNSGFI LNGDQCVPPT
SCGCYHQGRY HQGGEQFWDG EECQSLCTCN GTTGNVHCTP NSCGPQESCR VVEGKFGCHP
NPHGTCSASG DPHYITFDRR AYDFQGSCRY VLVTLCNATD ELNQFSVEAK NEALNGRPLS
IVAEVFVNGV TRNLPIVLNE GNVSVYATGS RILVSTNFGL SVTYNGYSAV FISVPPNYRE
KICGLCGNFN GNSNDDFHTP SGTIVTSPDE FGRAWKVPGN YTCNDGCGSS CPQCANEQPA
RDQCEVIQAA DGPFSFCYEE VDPAPYFNDC VFDVCLSGNQ GHDLLCSAIE SYVSACQSAN
VRIYPWRENT TCTLDCPANS HYELCGTDCG HTCASSIDET CEQFCSEGCF CDEGFIKSGT
RCVPVESCGC QYDGFYYDSF WTDGCSQRCE CHAPNDLRCS ASSCTPEQQC SIRDGQLGCY
DAMSTCTVWG DPHYITFDGA VAHFQGTCSY IITESTNHGT NETQFQVIAT NNHRGNNRVS
FVSAVDIYLS NHPESVYIRI GPNKRVNGND ASLPTTVGIL AQVVRQGSYI VVDASDLLVQ
FDGQSTLLVR LGQNRHDRVT GMCGNSNNDP SDDKVLPNGT LAQNDNYFGH IAVEITIDAS
TRQEEYSQLC SVITNTTGPF STCHLHSDPQ PFFSSCVYDL CLYTPANGML CSAVSAYEKT
CSVLGLDIPD WRSALHCGIP VCSPVSSCPV RSPVCSPVSS CPVRSPVCSS VSPCPPVCSC
PACSPVASCL PVARPPSCSV PGPALGASFW SDRTCAQKCT CTSTGLQCRN EPCSFSQICK
PASFQFSCQT VPRGTCTISG DPHYDTFDNT VFHFQGTCTY VLSEQCNSGR PYYRVEGKNE
HRGSTQVSWT RLVKVHIYFS HLIYLLVFLQ VNGNFASTPF SLSNGTVQVY DSGFSVFVST
DFGLVVSYDT NHYVQISLPY TYQNGTCGLC GNFNGIRRDD FQTRDGEVVS SDVVFANSWQ
AFGDDKPGCG PQCGGLDCAV CTVEETALYS NTDHCGILSS SSGPFTVCHQ QLPPQSFVDS
CVYDLCVGGG YRPILCQALS VYASQCQQSG IRLPSWRTPG FCEIPCPANS HFESEGTGCP
PTCVNPNSTH NCPLPPQESC ICDSGYILSG GVCVPHAECG CSLEGRYYRS GQTVILDKNC
GRRCSCSYGS ITFHSQGCGP FESCRLENGE GRCRPNSYET CWIRGPGSYQ TFDGLTYQYP
GTCRLTLAKV MGLSSHPHFM VTAEKVPRGQ QGFARILEWN TYLKLCSSFN IYLCVHRLNT
IFHSSIYSVI IRTSFGVTVQ TVWPHFVRVT APGVYNGSLG GLCGNYNGHP HDDFNTPNGV
LVNSSQDFGD SWRDGSLAAD CVQSMNQNST TNYNSTEYCG ILSSPDGPFV PCWSVVDPSQ
QVDVCVEIMG GSNNPASTLC GVLRDYALMC QQKGVALGQW RNATGCALTC PSNSHYELCG
SSCPSACPSL SFPFTCDTVC QEGCQCNSGF ILNGDQCVPP TSCGCYHQGR YHQGGEQFWD
GEECQSLCTC NGNTGSVHCT PNSCGPQESC RVVEGEFGCH PNLHGTCSAS GDPHYITFDR
KAYDFQGTCR YVLVTLCNAT DELNQFSVEA KNEALNERPL SIVAEVFVNV WGYNVHMSRD
RRGLVQVNGV TRNLPIILNE GNVSIYATGS RILVSTNFGL SVTYNRYRAV EKICGLCGNF
NGNPNDDFHT PSGTIVTSPD EFGRAWKVPG NYTCNDGCGS SCPQCANEQP ARDQCEVIQA
ADGPFSFCHE EVDPAPYFND CVFDVCLSGN QGHDLLCSAI ESYVSACQSA NVRIYPWREN
TTCSESTSLD CPANSHYELC GTDCGHTCAS SIDETCEQFC SEGCFCDEGF IKSGTRCVPV
ERCGCQYDGF YYDLGASFWS DRTCAQKCTC TSTGLQCRNE PCSFSQICKP ASFQFSCQTV
PRGTCTISGD PHYYTFDNTV FHFQGTCTYV LSEQCNSGRP YYRVEGKNEH RGSTQVSWTR
LVKVHVYNDT IELVKGRHGQ VNGNFAFTPF SLSNGTVQVY ESGFSVFVST DFGLVVSYDT
IHHVQISLPY TYQNGTCGLC GNFNGIRRDD FQTRDGEVVS SDVVFANSWQ ASGDDEPGCG
PQCGGLDCAV CTVEETALYS NTDHCGILSS SSGPFTACHQ QLPPQSFVES CVYDLCVGGG
YRPILCQALS VYASQCQQSG IRLPSWRTPG FCEIPCPANS HFESEGTGCP PTCVNPNSTH
NCPLPPQESC ICDSGYILSG GVCVPHAECG CSFEGRYYRS GQTVILDGDC GRRCSCSYGS
MTCHSHGCGP LESCRVEDGE RGCRPNSYET CWIRGPGSYQ TFDGLTYQYP GACRLTLAKV
MGLSSHPHFM VTAEKVPRGQ QGFTRILHFE AEGIHISIEM ARNSKVKVSE WNTYLKLCSS
FNIYLCIFHS SIYSVIIRTS FGVTVQTVWP HFVRVTAPGV YNGSLGGLCG NYNGHPHDDF
NTPNGVLVNS SQDFGDSWRD SSLAAHCVES MNQNSTTNYN STEYCGILSS PDGPFVPCWS
VVNPRHQVDV CVEIMGGSNN PASTLCGVLR DYALMCQQKG VALGQWRNAT GCALTCPSNS
HYELCGSSCP SACPSLSFPF TCDTVCQEGC QCNSGFILNG DQCVPPTSCG CYHQGRYHQG
GEQFWDGEEC QSLCTCNGTT GNVHCTPNSC GPQESCRVVE GEFGCHPNLH GTCSASGDPH
YITFDRKAYD FQGTCRYVLV TLCNATDELN QFSVEAKNEA LNGLPLSIVA EVFVNVWGYD
MHMSRDRRGL VQVNGVTRNL PIVLNEGNVS IYATGSRILV STNFGLSVTY NGYSAVFISV
PPNYREKICG LCGNFNGNPN DDFHTPSGTI VTSPDEFGRA WKVPGNYTCN DGCGSSCPQC
ANEQPTRDQC EVIQASDGPF SFCHEEVDPA PYFNDCVFDV CLSGNQGHDL LCSAIESYVS
ACQSANVRIY PWRENTTCSE STSLDCPANS HYELCGTDCG HTCSSHIDET CEQFCSEGCF
CDEGFIKSGT RCVPVESCGC QYDGFYYDLG ASFWSDRTCA QKCTCTSTGL QCRNEPCSFS
QICKPASFQF SCQTVPRGTC TISGDPHYDT FDNTVFHFQG TCTYVLSEQC NSGRPYYRVE
GKNEHRGSTQ VSWTRLVKVH VYNDTIELVK GRHGQVNGNF AFTPFSLSNG TVQVYESGFS
VFVSTDFGLV VSYDTIHHVQ ISLPYTYQNG TCGLCGNFNG IRRDDFQTRD GEVVSSDVVF
ANSWQASGDD EPGCGPQCGG LDCAVCTVEE TALYSNTDHC GILSSSSGPF TACHQQLPPQ
SFVESCVYDL CVGGGYRPIL CQALSVYASQ CQQSGIQLPS WRTPGFCEIP CPANSHFESE
GTGCPPTCVN PNSTHNCPLP PQESCICDLG YILSGGVCVP HAECGCSFEG RYYRSGQTVI
LDGDCGRRCS CSYGSMTCHS HGCGPLESCR VEDGERGCRP NSYETCWIRG PGSYQTFDGL
TYQYPGACRL TLAKVMGLSM KVSEWNTYLK LCSSFNIYLC TVWPHFVRVT APGVYNGSLG
GLCGNYNGHP HDDFNTPNGV LINSSQDFGD SWRDGSLAAH CVESMNQNST TNYNSTEYCG
ILSSPDGPFV PCWSVVDPSQ QVDVCVEIMG GSNNPASTLC GVLRDYALMC QQKGVALGQW
RNATGSLTCP SNSHYELCGT SCPSACPSLS FPFTCDTVCQ EGCQCNSGFI LNGDQCVPPT
SCGCYHQGRY HQGGEQFWDG EECQSLCTCN GTTGNVHCTP NSCGPQESCR VVEGEFGCHP
NLHGTCSASG DPHYITFDRK AYDFQGTCRY VLVTLCNATD ELNQFSVEAK NEALNGLPLS
IVAEVFVNVW GYDMHMSRDR RGLVQVSS
//