ID A0A3P8PJD9_ASTCA Unreviewed; 815 AA.
AC A0A3P8PJD9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSACLP00000017127.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000017127.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000017127.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000017127.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8PJD9; -.
DR STRING; 8154.ENSACLP00000017127; -.
DR Ensembl; ENSACLT00000017541.1; ENSACLP00000017127.1; ENSACLG00000011665.1.
DR GeneTree; ENSGT00940000163991; -.
DR OMA; YDSCIAV; -.
DR OrthoDB; 4022492at2759; -.
DR Proteomes; UP000265100; Chromosome 14.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 548..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 549..813
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 815 AA; 90197 MW; 7712B62F065DABD8 CRC64;
MDGDFTIGGI FSIHNYVHTV NNNYTTMPEP VRCSGSMESR ELRFSRAMIF AIEQINNSTD
LLPRIKLGYQ IYDSCASVLV AVHVAFQFLN SLDPVFYIGN NCSQSGMVMA VVGESGSTPS
ISLSRVISSF KVPQVSHFAT CACLSDKQQY PNFFRTIPSD KFQAGALAKM VKHFGWTWIG
AVRSDSDYGN NGMASFLQAA QKEGICVEYS VSFYRTHPHS RIQRVADVIR RSTAMVIVAF
AAIGDMAILL EELSHNPSPP RQWIGSEAWV TSPELMRYSF CAGAVGFGIQ KSLIPGLRDF
LLNLSPSQVA ASALLTEFWE DAFNCTLKKS AAATKNNVCD GKEDILNLQS PYTDTSQLRI
TNMVYKAVYA IAHAIHNAVC QRKNVTSQCD KLTRLESKQV LNQLKTVHFS QNGNDMSFND
NGDPVAIYEL VNWQKSKSGD VKMVSVGLYD ASLPVGQEFR INRNITWMEG TTKVPVSVCS
ASCPPGTRKM LQKGKPICCY DCIPCPEGEI SNTTDSSDCL PCHKEFWPNA KRDTCIPKPV
EFLSFQDILG IILATFSVLG ACLAIITGAV FFYHRTSPIV RANNSELSFL LLISLTLCFL
CSLTFIGAPS DWSCMLRHTA FGITFVLCIS CVLGKTIVVL MAFKATLPGS NVMKWFGPPQ
QRMTVVSFTF IQVLICTIWL VLSPPFPIKN LTTYKEKIIL ECDLGSPVGF WAVLGYIGLL
ASFCFVLAVL ARKLPDNFNE AKFITFSMLI FCAVWITFIP AYVSSPGKFT VVVEIFAILA
SSFGLIMCIF APKCFIILFK PEQNTKKNLM NKNQS
//
