ID A0A3P8PJQ0_ASTCA Unreviewed; 796 AA.
AC A0A3P8PJQ0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Cadherin-18-like {ECO:0000313|Ensembl:ENSACLP00000017286.1};
GN Name=CDH18 {ECO:0000313|Ensembl:ENSACLP00000017286.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000017286.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000017286.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000017286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3P8PJQ0; -.
DR STRING; 8154.ENSACLP00000017286; -.
DR Ensembl; ENSACLT00000017704.1; ENSACLP00000017286.1; ENSACLG00000011780.1.
DR GeneTree; ENSGT00940000157512; -.
DR OMA; RTMQDVY; -.
DR OrthoDB; 3667774at2759; -.
DR Proteomes; UP000265100; Chromosome 9.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF106; CADHERIN-18; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..796
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018201682"
FT TRANSMEM 616..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 161..269
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 270..384
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 385..489
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 489..606
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 743..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 88375 MW; 93CADD97D1E5F559 CRC64;
MRISTTSCLC PFLVCLCFIQ RCSGASHHVP TKVPSKNQTK LANGETEVHH RPKRGWIWNQ
FFVLEEHMGP DAQYVGKLHS NSDKGDGSVR YILSGEGAGT IFIIDEVTGD IHATKSLDRE
RKTHYVLHAQ ALDRNTEEAL EPKSEFIIKV QDINDNAPKF PDGPFVASVP EMSEVGTSVL
QVTATDADDP TYGNSARIVY SILQGQPYFS VDPKTGIIRT ALANMDREAR EHYTVVIQAK
DMAGQVGGLS GSTTINITLT DVNDNPPKFP QKNYQLYVPE SAQVGKPVGK IKANDEDLGV
NADIRYSIII SEGANMFSIS ADRDTREGII SLKKPLNFER KKTYTLNIEG VNTHVDPRFS
YLGSFKDTAT LKITVGDVDE APVFSMDYYI MDVYENSPSG TEVGAVTARD PDSRNSHVRY
FLDRKEEGIN YFRVDEYSGV IYTTLPLDRE DMPWHNITVM ASEVDNPSLL SHVPVTVQVL
DVNDNPPEIA TDEEVIVCES SRPGQVIQTV TAVDKDDFAN GQRFSFASPS QLPVNPNFTL
KDNEDSTASI IARRRRFNHL TQELYELPIV VWDGGEPSLS GTSTLTLRVC PCQRHGRIRM
CQGEAFLSSA GLSTGALIAI LLCIVILLAI VVLFITLRRS KKEPLIISEE DIRENVVTYD
DEGGGEEDTE AFDIIALRNP AAAEELKFRR DIRPEGRKHC GPPRIHRSPS VELDEVDVHQ
FIKQKLVEAD MDTSVPPYDS LQTYAYEGQG SPTGSISPLD SPGTHSEQDF NYLDNWGPQF
QKLAELYGDP ESDVTT
//