ID   A0A3P8PL54_ASTCA        Unreviewed;       856 AA.
AC   A0A3P8PL54;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000017742.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000017742.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000017742.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3P8PL54; -.
DR   STRING; 8154.ENSACLP00000017742; -.
DR   Ensembl; ENSACLT00000018164.1; ENSACLP00000017742.1; ENSACLG00000012096.1.
DR   GeneTree; ENSGT00940000166814; -.
DR   OMA; ELINTFW; -.
DR   Proteomes; UP000265100; Chromosome 14.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF546; OLFACTORY RECEPTOR C FAMILY, U1 PRECURSOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..856
FT                   /note="G-protein coupled receptors family 3 profile domain-
FT                   containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018137711"
FT   TRANSMEM        588..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        625..646
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        658..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        702..721
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        751..772
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        784..804
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        816..840
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          588..854
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   856 AA;  95439 MW;  8E582AB47B6DC2D9 CRC64;
     MKKCTDKCIE FLTLLISLLR SMLENQSQET VFSTQSFYTT EDPVALHSDG DVVIGGFFPL
     HYVASKPEYS YNSEPQVTSC SGFDHIAFRW MMTMVFTVDE INRNSSLLPG VKLGYRIMDS
     CDHVHTSLQA LFSLISYSKT TREYSPCLNY SPVPAVIGLA SSTPTRAVAH TLGPFNIPLV
     SYFATCSCLT DKHLYPSFLR TVPSDLFQVR GLVKLVTFFG WFWVGTIGAT DDYSLYGIQA
     FSIQFGQQGG CVAFHLTIPT SPTVAEIQKM ADKLQRSTAR VVVVFAKEVN LLDLFSEVSI
     SRNMTGIQWV VSEAWMAANQ LTTPDFHNLL EGTLGFSFPG VSIPGLKEFL LNVRPSPKPG
     MELVNVFWEE YFGCKLEFER DKSALKKTVC TGLEDLSYRD SSYSDVSQAR ISYNVYKAVY
     AVAHALHTFL NCNSTGPTGG LCEMHNSFTT QRSVYFDSNG EPVPLYDIIN WQKDSKNEIS
     FVKVGNYDGS AQQGQQLQIL KNTIVWTTRQ SQVPVSQCSA PCPPGSRQAT RQGEPKCCFD
     CLPCADGEIS NQTGSTECIK CPEYFWSDKE KVKCVAGEEE FLSFSDTMGI ILVAITLLGF
     ILTTIITIVF HSFRFTPIVK ANNSEISFLL LLSLKLCFLC SLVFIGQPSW WTCRLRQAAF
     GISFVLCLSC LLVKTIVVLL AFQTNVPVSR GRMLFGTFQQ RILILCTTAP QICLSTGWVL
     GAPPFPFRNS NYQVITGKIV VECKEPWPPG FYLLLGYIGL LAFACLLLAF FGRKLPDTFN
     EAKFISFSML IFWAVWISFI PAYVSSPGKF SVAVEIFAIL ASSFGLLLCI FVPKCYIILL
     HPERNIKKGM TGKNPR
//