ID A0A3P8PLR2_ASTCA Unreviewed; 1763 AA.
AC A0A3P8PLR2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSACLP00000017948.1};
GN Name=RICTOR {ECO:0000313|Ensembl:ENSACLP00000017948.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000017948.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000017948.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000017948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8154.ENSACLP00000017948; -.
DR Ensembl; ENSACLT00000018378.1; ENSACLP00000017948.1; ENSACLG00000012088.1.
DR GeneTree; ENSGT00390000002096; -.
DR OMA; GRTHEGH; -.
DR Proteomes; UP000265100; Chromosome 12.
DR Bgee; ENSACLG00000012088; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029259; RICTOR_phospho.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14665; RICTOR_phospho; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01309; RICTOR_phospho; 2.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
FT DOMAIN 57..439
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 521..740
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 918..990
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 1017..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1763 AA; 196003 MW; 23ED3B49FE6F87DB CRC64;
MAASFRGRPI RSLRMRGRND SGEENVPLDL SREPSENFRE ILQNVAKPHG VSNMRKLGHL
NNFIKLLCSI GHREENFGFT YEEIIICLRL ALLNEAKEVR AAGLRALRYL IRDTSVLQKV
LRLQVDYLIA RCIDIQQSNE GERTQALRLV RKIITVNAML FPTSIANSLI AVGTDGLQER
DRMVRAAIAI VCELALKNPE VVAKRGGLST ILKSVIDCQL SRINEALITT ILHLLNHPRT
RQYVRVDVEL EQILAPFTDF HYRHNADTAE GQLKEDREAR FLSSRMAIVA AFRSWSGIIN
LCKAGNSGIQ SLIGLLCIPN MEVRKGLLEV LYEIFRLPVP IVTQDFTEAL LSVDPARFQD
TWRLSDGFVA AEAKVILPHR ARSRPDLMDN YLAFVLSAFI SSGLLEGLVE VVTSSDDQLA
VRATILLGDL LHMANTILPH SHSHHLHCLP TLINMAASFD IPQEKRLRAS AAVNNLKRFH
EKKKKGLKPH SLYLDHIIRK SVSSHNRRDS RVHKDIYVIK DTEEALMMNL RDSQILNHKQ
NLEWNWLLIA TILKWPNVNL RNNKDEQMHK FVRRLLYFYK PSSKLYAGLA LDHLKARQLT
VVGCQFVEFL MDSDEDGQGY LEDLVKDMVS WLSSSSGMKP ERCLQSNGLL TTLSQHYFLF
LGTLSAHPQG VKLLEKCGLF QCLLNLCSVK NQDAVLKLAV STLDYSRDGL ARVILSKILT
ASTDTCRLYA TKHLRVLLRA GVEFFSSWGM ELLVTQLHDH NKAVSMEALD ILDEACEDKA
NLHALIQLKP AVSHLGDKGL LLLLRFLSIP KGFSYLNERG YVSKQLDKWQ KEYNLKYVDQ
IEEQLNEALT TYRKPVDGDN YVRRSNQRLQ RPNVYLPVHL YGQLVHDKTG CHLLEAQSVV
PDLSYTIRSP MLDTWEGIKQ LKAALWALGN IGSSNWGLNL LQEENVIPDI LALAQHCEVL
SVRGTCVYVL GVITKTKQGC EVLKQFGWDA VRHSRRTLWP VTPDEVDTQL TSELSSVPST
LSLNSESTSS RHNSESESQP NMYILDDDKC DVLDQSDETS LYLHSKPVKD RSPFTILAST
RFVRTRFLNS LSLPSKKLRS TSDPKTPSGS RTPTELKTGS MRRNRTVTEP SVYSPNQGDF
TPIFNGRGMP KSPTVSLETS FVGTRGGSEE HLVDGRLSKG GGSGLGLSTL GGQGAAEQHS
REREQSSRER LAGDGGSSSG GNVGGGGGGT QFKSRSQSFN TDTTTSGISS MSSSPSRETV
GNPEHPEAEP DSSDCVSLNT VVSAKTVKTL SSLTPQSQTN HMSTSKSSTV SLVPPGSSHT
LPRRAQSLKS PSVTTIKSLA DCSFMYTSPR DALGYATLKR LQQQRIHPSL SHSEALASPA
KDVLFTDTIT MKSGSLDSRL TPRRVSFCAP SAVSVRISDR RVTCPEPSAV SSYRRLSRTL
VPRFLKALSF ASLDKEELLS PINQSTLHRC SSVRSMVSSV TFGCNDDYIG LALPMDIHDM
FHIRDSAYFQ QRISPPSEER KRFLFGDGDG DRPALPVLKQ QFSISELIVH RGDTPNHMVG
SEETGLQVHT EENCLYCVGA IVLGYPTQPL INSTHSRTDF VDFPSWGGQS GHRLEVMPQS
KFSGVSGCSD AAVSQGSVSG TPTPGDIVIG GKAISEDGPA SRVLLRKEVL RLIINLSSSV
GTKGHETGLL TIKEKFSYAF DDICLYSEVS HLLSHCAFRL TSRRFIQELF QDVQFMPMFE
EAEAILTKQP KPVEEDADPP EES
//
