ID A0A3P8PM95_ASTCA Unreviewed; 560 AA.
AC A0A3P8PM95;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSACLP00000018133.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000018133.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000018133.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000018133.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3P8PM95; -.
DR STRING; 8154.ENSACLP00000018133; -.
DR Ensembl; ENSACLT00000018563.1; ENSACLP00000018133.1; ENSACLG00000012258.1.
DR GeneTree; ENSGT00530000063725; -.
DR OMA; CICIANP; -.
DR Proteomes; UP000265100; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096:SF5; PERFORIN 1.3-RELATED; 1.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 18..362
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 385..501
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 560 AA; 62068 MW; 5CDBBAC9D73BF178 CRC64;
MLQWSPLCLP SSVSFIGTPQ ECEKAHFVPG YNLGGEGFDI VTMERKGAYV IDTETWKIGN
GSCRMYCNRY MNGEKQKVPV AVVDWRTLPK CSLKVSSVVY DSVETLVNDS TSSVSNNWTI
GLDIPVDPSA KVGVGFGGSH SRDSTFAMKK SKQDRYTFLH HSINCHYYGY RLATSPPLSQ
EFKPAVDSIP PYSSKTAPLY HNLIDTYGTH YITQVSLGGE IKASTAVKTC MATMNGLTDT
DVSDCLSVEA SASFANSASI NATIDHCQRK KKMLGSNQTF SSSFNERRTE VIGGDIDGGD
ILFVGQSDPS VYKNWLISLK SIPDVVQYNL KPLHTILPLN HPARAGLKQQ VEQYIKKNAV
LKKCSETCKI GHRSNARDPC ACVCNSNQNI KSNCCPAGKG LATLKVFKLY AKGLYGDDWS
QTDGSVEVTY GDQKKRTDII SNDDNPRWRE TFEFGTITIN MKNKLKFAVY DEDTYWNSDL
LGECSFDLRA GKVSDSCMLN HGTFFFSYIV ECAPSLSGNQ CQEYIPSAMS PSLAEVFHTR
NGVLLGKMWN KYEKPANERL
//
