ID A0A3P8PQ04_ASTCA Unreviewed; 1473 AA.
AC A0A3P8PQ04;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Protein Shroom2-like {ECO:0000313|Ensembl:ENSACLP00000018969.1};
GN Name=SHROOM2 {ECO:0000313|Ensembl:ENSACLP00000018969.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000018969.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000018969.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000018969.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
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DR STRING; 8154.ENSACLP00000018969; -.
DR Ensembl; ENSACLT00000019411.1; ENSACLP00000018969.1; ENSACLG00000012906.1.
DR GeneTree; ENSGT00940000155212; -.
DR OMA; SAGRMKW; -.
DR Proteomes; UP000265100; Chromosome 23.
DR Bgee; ENSACLG00000012906; Expressed in camera-type eye and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF38; PROTEIN SHROOM2-LIKE ISOFORM X1; 1.
DR Pfam; PF08688; ASD1; 2.
DR Pfam; PF08687; ASD2; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701}.
FT DOMAIN 643..703
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 1169..1466
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 28..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1261..1326
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1357..1420
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 82..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..928
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1473 AA; 162941 MW; 26820FA498A8F0EC CRC64;
MVDVVSPSTM PSETEVHVAR SFLTKILRSS MRKNRFKGKN DPGSRPHSWY ASKLTEEEPP
EREATQAPVW QPKHEARPKE SSTQGDQNIQ HQQTSQISSV KNMEKLERPS HPYPAGRLSP
NKYTSSAEPI CGLGPGKRDS GFSCFSSGSS PPVHDLNASG RKGTSTESIF FKGVHNEGPQ
QNERPRYLQP TLGNGGWKEQ PASRVSIAGR PNVGPVWQVP DRKKSQSPPP PPPPLRSDSF
AATKVFPYSE GPAKSHGTSF EKLPESNHHN GIRSHQEKSS ETRRSFNPIP AKDFLHPNMP
ADYNHNQLNP NKHFSLSSSD VRQFHYTQPP AHQRQFSDES PFYFLQTGKA PPTKTQSVGS
YYRSLQDLPT NAFSRRQMPH SAASMVSTAT NPNLESGGHK RYYGLASKTA QYKARQGKTE
SRMTETEKHH WVNSNETGYP SSLKTNTKAK YSLPQSQIPY IENKECHTHS HFGNGLHYNH
QTSEISVQRR SPEDTAKRGE GHTNDMKIQF PVHQVKDHKA NLPRHQDPWV PQEDQRITAL
KTPLLHSLTL ENKTLAATTT TVLSTQDTSD TMAASSGKAN RRSDRYATTL RKEIQQKRAQ
LQKSRSAATL TCDAEDEDAE EWRSMEASAS SAASYSNTYK DHLKEAQARV LQATSFQRRD
LEPQGPEASV LKTSNGRTRG RKRCQLAKRT HSFSEPDKID KVGVEGESQA GTFGERRKFF
EAKPAFSRPV LKSSQSANSN TDLDESGKPQ ERAPSIGSVE PPPSTDPNHL NPGHNEVLLE
QQRLGTFAEY QATWNKQKKS SEGKTQGRYH SAENILDAGA EEKAICIHER SRSSPSADFY
TQKIPSSWRD TQAQKGSLAT RVKSESRSYE PDNSPQLVEG PSPGFPDQRT NPAAIPAHTT
LSSGPRSLSP SPGSKHPAQP PQTQSLLPPP RPHLGLETTS SSQEFLAGAQ ADPAGVQPLS
SAASDTQHHA ATSTAAADQV SSAGPASASS PRLREMSCAD ESKAAQGHEV KEQPASPSPS
SSPLSSSTSC TAPLPLPVPD GARSPSPHFA PLRLTDRPPA ASVQNDSLLR SDSESKRPAV
MDVSGQVRKV PVRIIHAETS TGREGRAYLP QNSGSCSLSE LPPRIPSLGA AERLSSSRFS
TYNRQAAQES APETSSPGPQ HSEEDAKREE LVRDIMGKDK SLVDILDQSG RKTTMDLMEG
LFPPEEEILE GAQQRRKAST GSRLLTSSPR STDRREEEEV SVSAAASLVP SSSYYNTSAP
KAELLIKMKD MQEQLEEQDS EDELDVDLVN KKQELISSLA KKLEVLREAR QSLQEDVEDN
EALGREVEAI VQRVCQPNQL DKFRMFVGDL DKVVSLLLSL SGRLARVENA LNSLEDEAPP
EEKQTLTEKR KLLMRQHEDA KELKENLDRR ERLVSSIMEA HLDMESLDDY RHFVKMKSAL
IIEQRKLEDK IKLGEEQLKC LMDSLPLEQR PLL
//
