ID A0A3P8PQB3_ASTCA Unreviewed; 390 AA.
AC A0A3P8PQB3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Plasminogen activator inhibitor 1 {ECO:0000256|ARBA:ARBA00040523};
DE AltName: Full=Endothelial plasminogen activator inhibitor {ECO:0000256|ARBA:ARBA00041825};
DE AltName: Full=Serpin E1 {ECO:0000256|ARBA:ARBA00043166};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000019255.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000019255.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000019255.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR AlphaFoldDB; A0A3P8PQB3; -.
DR STRING; 8154.ENSACLP00000019255; -.
DR Ensembl; ENSACLT00000019700.1; ENSACLP00000019255.1; ENSACLG00000013078.1.
DR GeneTree; ENSGT00940000160621; -.
DR OMA; IQHKQTG; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000265100; Chromosome 3.
DR Bgee; ENSACLG00000013078; Expressed in anal fin and 3 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0010757; P:negative regulation of plasminogen activation; IEA:Ensembl.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF49; PLASMINOGEN ACTIVATOR INHIBITOR 1; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..390
FT /note="Plasminogen activator inhibitor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017979131"
FT DOMAIN 29..388
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 390 AA; 43730 MW; 5C22E49030D22B63 CRC64;
MLCVYIFLVL ALSRVGLSSL QDKQTDFGLK VFYQLAQEST DKNVVLSPYG VASVLAMAQL
GANGNTSKAL TTAMGFSLQE RGMLRQQWLL QRGLSTEEGV EIANGVMVER KMNLEKRYHR
TLAKAFKTNP HQVDFTKPDQ AISVINAWVS DHTAGLIPEF LQSGSLTDQT RLILLNALHF
QGLWKIPFDP KLTQERMFHC ANGSTVPVHM MRITNRFNYG EFVTADGVDY DVIEVPYEGD
LLSMLLVSPF EPEVPLSTLS ADLSSQKIRQ WRTELRNVRR QLALPRFTLD SEVNLKTALV
NMGLGDIFNP ATADFTRITL DQRLCVSKVL QKLKIEVNEE GTKGAASTAA VLFSRMAVEE
IILDRPFLFL IQHKLTGAVL FMGQFNQPQQ
//