ID   A0A3P8PQH6_ASTCA        Unreviewed;      1383 AA.
AC   A0A3P8PQH6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE            Short=PARP {ECO:0000256|RuleBase:RU362114};
DE            EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000019243.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000019243.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000019243.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC       {ECO:0000256|ARBA:ARBA00024347}.
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DR   STRING; 8154.ENSACLP00000019243; -.
DR   Ensembl; ENSACLT00000019688.1; ENSACLP00000019243.1; ENSACLG00000013074.1.
DR   GeneTree; ENSGT00940000154311; -.
DR   Proteomes; UP000265100; Chromosome 3.
DR   Bgee; ENSACLG00000013074; Expressed in testis and 4 other cell types or tissues.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd01439; TCCD_inducible_PARP_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.90.228.10; -; 1.
DR   Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 2.
DR   InterPro; IPR002589; Macro_dom.
DR   InterPro; IPR043472; Macro_dom-like.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR   PANTHER; PTHR14453; PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR14453:SF102; POLY [ADP-RIBOSE] POLYMERASE; 1.
DR   Pfam; PF01661; Macro; 1.
DR   Pfam; PF00644; PARP; 1.
DR   SUPFAM; SSF56399; ADP-ribosylation; 1.
DR   SUPFAM; SSF52949; Macro domain-like; 2.
DR   PROSITE; PS51154; MACRO; 1.
DR   PROSITE; PS51059; PARP_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW   NAD {ECO:0000256|RuleBase:RU362114};
KW   Transferase {ECO:0000256|RuleBase:RU362114}.
FT   DOMAIN          786..955
FT                   /note="Macro"
FT                   /evidence="ECO:0000259|PROSITE:PS51154"
FT   DOMAIN          1167..1383
FT                   /note="PARP catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51059"
FT   REGION          78..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1383 AA;  154201 MW;  8B165FF5009360A4 CRC64;
     MDEYPYPLFF EATDFTDREK EKVRRYFQKR RESGGGDCGN LEKLGGSVYK ICFKEKEDQD
     RVLQRKFHTI TLPSGQVRLT VSRTSSPQTS DQPMPSQSLS STNPNINGLE KTFRIDVFLL
     FFLRDNCKAY TFFEKQLSSI GCTMELNFDE EEVLVRGEVD KGPGGGLGGA AEKWEYQVNQ
     AFVQLTESYN CYHVLEPKQV KIVLQDSAFK TDDIKVYTES GYAVVVGEVD AVKEKIAILE
     KSLPTKKEVP IVEKNFKLIE EDLNREMRAN CPEVTIIRGS AMITLEGPDK EVQSGAAKLV
     ELIKNIKEKS VKFPTALLTF MKTSDAIPKY QTRFLQSLRN PVFFEVGADV VLSSLSSDAL
     NEAEAAVMRD FKVTTVQLQG AIDLNRLKEI LTKAKNEANS REFRVDISYM PGTRGTSTTK
     VRLVGYSENV AKLNEVLHDF QLNQVSTQET INLLHHDTVY CFNKILDLIG MKQTKVTLQA
     SHFPNPCVFV SGPRCHVQEV KEALTSTLDS VVVDTLTLDG PGAQQYFQEE GKVTKELIEG
     SCHVIIREKQ TAAIPNVQRP RNTSRLSDTP RSLSYSSSMY STVGNSAINR TNLKIKLSSL
     ENEQVDVLVV PMLNKQLTST NIGKSLLAKA GNVLKLKFDS VLASCALAPG DVQLVDAPPS
     LGCSKIFFIE CLPWDGVRGK SVQALGNGLQ KCLELCVRQN FGSVAIPIIG PGIVLQYPLR
     EAIQVLTDII HQFGLSASSG SLTNIHIVIK PGYPDSEECY HDVYKQLGLN MNQGGQAIFR
     SLTSDLDDIV ITVGSGVKLH VVFGDITNET TDAVVNITDS QSFNFDISTL AEPQAAATVN
     RGEIFVTQSG NFLSKAILHV HGEQDEVLIE QLVCDIICYC ESHKYNSVAI PAMCAGAGGL
     DPAIVAGAIF RGIKSSASIM TSLTDIRLIL IKIDVFLTFK EEAMQMYSPA VINRVLPVLP
     VLPVQVQQQQ PPHSVSAYLS SLQISSTSQQ SVFTFLGLSK KDVDDAMEKL KHQYQTQCSS
     NTFSKEELEP LDQDDMMELK ELVESEGLFM QTDQAGTLTV SGLKDGVTRV MQKMNQCQLM
     ALAREVRVRE EEDLYLRVVW CILAHNGNWE RLPRTANHQL ESDELTEGIT DAQGLTWEVN
     LQRMVATQSL RQTTKLKRLE NLTDFTFPLY WDSMAASENM MVIPLESSSA EYRTVKEAFK
     RTVAKTVMKI DRLQNVHLRR AYEAQKKHIS DKNAQEGGAG EKLLYHGTTQ ENCNSIMKTG
     FNRRFAGQNA CTSRVFVTPK ESTARRLRAT SYGRGTYFAV NANYSAHPTY SKPAADGSQL
     MFVARVLTGV CTHGRHDMKV PPPRNHQQPH DRYDSVVDRI DNPSMYVVFH DNQAYPDYLI
     TFK
//