ID   A0A3P8PR25_ASTCA        Unreviewed;       578 AA.
AC   A0A3P8PR25;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000019511.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000019511.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000019511.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8PR25; -.
DR   STRING; 8154.ENSACLP00000019511; -.
DR   Ensembl; ENSACLT00000019961.1; ENSACLP00000019511.1; ENSACLG00000013275.1.
DR   GeneTree; ENSGT01080000257342; -.
DR   OMA; WELTISF; -.
DR   Proteomes; UP000265100; Chromosome 15.
DR   Bgee; ENSACLG00000013275; Expressed in anal fin.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   InterPro; IPR015095; AlkB_hom8_N.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR47510; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47510:SF3; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF09004; ALKBH8_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          156..422
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          50..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..89
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  64641 MW;  0C92B85365A5728A CRC64;
     MQQQISENDS ASVWKGFRNI TNYKPKTPHS TDDLLLANTL NDFYCRFDEP SGSLHTSNDP
     NNRGTLDTHS PTSPPSIEPS PPSNCSPATP APSPHTKEDF TPPPPTTTLH IHEADVRKQF
     KNLNARKAPG PDGVSPATLR HCANELAPVF SGIFNSSLQA CHVPACFKSS TIIPVPKKPR
     ITGLNDYRPV ALTSVVMKSF ERLVLSHLKT LTAPLLDPLQ FAYRANRSVD DAINMALHFI
     LQHLDSPGTY ARILFVDFSS AFNTILPDHL RGKLSQMNVP DPICRWITDF LTDRKQHVRL
     GKNVSDSRTI STGSPQGCVL SPLLFSLYTN CCTSTHQSVK LIKFADDTTV IGLISDGDES
     AYRREVERLV SWCSHNNLVL NAQKTVEIIV DFRKHTAPLP PIILTDTPIT SVDSFRFLGT
     TITQDLKWEP TITSVIKKAQ QRMYFLRQLK KFNLPTRTMM QFYTAIIESI LTSSITVWYA
     GATIRDKQRL QRVVRSAEKV IGCRLPSLQD LYTSRTLRRA ARISADPSHP GHSLFDLLPS
     GRRLRSIRTR TSRHKNSFFP SAVGHMNNNH MTVPATNT
//