ID A0A3P8PSC5_ASTCA Unreviewed; 445 AA.
AC A0A3P8PSC5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Fatty acid desaturase 2-like {ECO:0000313|Ensembl:ENSACLP00000019966.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000019966.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000019966.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000019966.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005105}.
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DR AlphaFoldDB; A0A3P8PSC5; -.
DR STRING; 8154.ENSACLP00000019966; -.
DR Ensembl; ENSACLT00000020428.1; ENSACLP00000019966.1; ENSACLG00000013528.1.
DR GeneTree; ENSGT00950000182990; -.
DR OrthoDB; 294339at2759; -.
DR UniPathway; UPA00658; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000013528; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF12; ACYL-COA 6-DESATURASE; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR PRINTS; PR00363; CYTOCHROMEB5.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 4: Predicted;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..96
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
SQ SEQUENCE 445 AA; 51879 MW; 026B8DF2B7688853 CRC64;
MGRGSQQTVP GEPDSGKAKG VYTWEEVQSH NSRNDQWLVI DRKVYNITQW AKRHPGGFRV
IGHYAGEDAT EAFTAFHPDS KFVQKFLKPL LLGELAATEP SQDQDKNAAI VQDFKTLRAQ
VEKQGLFQGQ PLFFFLHLGH IVLLEALGWM LVSMCGTGWI PTLLCSVILA TAQAQAGWLQ
HDFGHLSVFK KSTWNHAVHK FVIGHLKGAS ANWWNHRHFQ HHAKPNIFTK DPDINTLDTF
VLGQTIPVEY GIKKIKHMPY NHQHQYFFLL GPPLLIPVFY NFNIMHTMIT RRYWLDLAWA
MTYYLRYFYY YAPLYGVFGS VALFFFVRFL ESHWFVWVTQ MNHIPMDIDH EKHKDWLTIQ
LQSTCNIEQS FFNDWFSGHL NFQIEHHLFP TMPRHNYHLV APQVRALCEK HGIPYQEKTL
WRGLADIVTS LKTSGDLWLD AYLHK
//
