ID A0A3P8PSZ1_ASTCA Unreviewed; 773 AA.
AC A0A3P8PSZ1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000020098.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000020098.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000020098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR AlphaFoldDB; A0A3P8PSZ1; -.
DR Ensembl; ENSACLT00000020560.1; ENSACLP00000020098.1; ENSACLG00000013637.1.
DR GeneTree; ENSGT00940000158458; -.
DR Proteomes; UP000265100; Chromosome 4.
DR Bgee; ENSACLG00000013637; Expressed in ovary and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002249; Cl_channel-7.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01118; CLCHANNEL7.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 253..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 340..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 376..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 480..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 514..538
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 709..767
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 85713 MW; 0B7060632861DE13 CRC64;
MANITKKVSW SSRGDDSGLT GEGTPLLNGS EIPKPSRQDP IRGRPKEIPH NEKLLSLKYE
SLDYDNIENQ LFLEEERRMS PMGFRCLEIS RWVICGLIGI LTGLIACFID IMVEKLAGYK
YQVIKENIEK FTEVGGLSIS LILWAVLNCA FVLVGGIMVA FFEPIAAGSG IPQIKCYLNG
VKIPRVVRLK TLVVKVIGVI CSVAGGLAVG KEGPMIHSGG VVAAGVSQGR STSLKRDFKM
FEYFRRDTEK RDFVSAGAAA GVSAAFGAPV GGVLFSLEEG ASFWNQMLTW RIFFASMIST
FTLNFFLSIY HGKPGDLSNP GLINFGRFES DSVAYYYYEI PLFMCMGALG GLLGALFNSL
NYWLTIFRIR YVHRPCLQVM EALLVAAVTA AVSFTMIYFS NDCQPLGPER NEEYSLQLFC
ADGEYNSMAT AFFNTPERSV RSLFHYQPGS YNPMTLGLFT LTYFFLACWT YGLAVSAGVF
IPSLLIGAAW GRLCGILLAS FTPTSPIWAD PGKYALIGAA AQLGGIVRMT LSLTVIMVEA
TGNVTYGLPI MLVLMIAKIV GDYFQEGLYD IHIKLQSVPF LHWEAPATSH WLTAREVMSS
PVTCFNRIEK VGTIVDVLSN TSTNHNGFPV VVQVLDSDEP AKLCGLILRS QLIVLLKHKV
FVELARSRLS QRKLQLKDFR DAYPRFPPIQ SIHVSQDERE CMMDLTEFMN PTPYTVPQDT
SLPRVFKLFR ALGLRHLVVA DDVNRVIGLV TRKDLARYHL GKHGLEELQL AQT
//
