ID   A0A3P8PUG9_ASTCA        Unreviewed;       259 AA.
AC   A0A3P8PUG9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000020633.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000020633.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000020633.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential for the proper assembly of the glomerular and
CC       tubular basement membranes in kidney. {ECO:0000256|ARBA:ARBA00037411}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
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DR   AlphaFoldDB; A0A3P8PUG9; -.
DR   STRING; 8154.ENSACLP00000020633; -.
DR   Ensembl; ENSACLT00000021111.1; ENSACLP00000020633.1; ENSACLG00000014011.1.
DR   GeneTree; ENSGT00940000157760; -.
DR   OMA; CCKTPSN; -.
DR   OrthoDB; 2913577at2759; -.
DR   Proteomes; UP000265100; Chromosome 7.
DR   Bgee; ENSACLG00000014011; Expressed in muscle tissue and 3 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd03155; CD151_like_LEL; 1.
DR   Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282:SF487; CD151 ANTIGEN; 1.
DR   PANTHER; PTHR19282; TETRASPANIN; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361218};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
FT   TRANSMEM        62..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
FT   TRANSMEM        90..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
FT   TRANSMEM        226..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361218"
SQ   SEQUENCE   259 AA;  29199 MW;  185EB07B925C14DE CRC64;
     MEVRREKKHA CGTICLKYLL FLFNVLFWLA GGAVLAVGVW TLVEKSDYIS LLSSSFYATS
     AYILIAAGVI VIVTGIIGCC ATLNEMKSLL IVYLILLLCI FLLEIIAGVL AYINYQECFP
     FCYQLDEELK QNLKVTMQQK YQQPGEESIT QAVDKLHQEF KCCGSHNFSD WSDSVWIQAA
     ENERLVPDSC CKTPGELCGR RDHPSNIYRV EGGCIMKLEE FLLSQLYILG AVGIGIAFLQ
     LLGMMFTCCL YRNLKEDPY
//