ID A0A3P8PW09_ASTCA Unreviewed; 1419 AA.
AC A0A3P8PW09;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Regulating synaptic membrane exocytosis 1a {ECO:0000313|Ensembl:ENSACLP00000021193.1};
GN Name=RIMS1 {ECO:0000313|Ensembl:ENSACLP00000021193.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000021193.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000021193.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000021193.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSACLT00000021683.1; ENSACLP00000021193.1; ENSACLG00000014225.1.
DR GeneTree; ENSGT00940000155134; -.
DR Proteomes; UP000265100; Chromosome 13.
DR Bgee; ENSACLG00000014225; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF18; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 21..178
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 106..166
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 506..599
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 651..776
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1265..1383
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1065
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1419 AA; 155201 MW; DB52A8A0774C8E0C CRC64;
MFASVGPRGG PRPPVAPAIP EPDLSHLTED ERKIIMAVLA RQREEEAKEE AMLKEEKPIQ
ARTVNLVGQK KPPQQNDVRG IQQQLSSYRE TVIRQATAAA GSAIHRDDAP TCGICHKTKF
ADGCGNPCSY CQTKFCARCG GRVSLRSNTE DKVVIWVCNN CRKQQEILTK PGEWFTGPPG
KPAGLGSAVS EPSVCQAPGD KKLRSRSQAP PGSTTAIYDP NRPSAPGTAP GTDARSLSEP
PRDTRNGRGG GAGRGERRQG QPRLKTQVSM DRDLRGESRE RRESRRLTKG RSLEHDPVGG
VGVRRTEEGD YHHMDHTGAP PRQAGPVPPG GRGHPVPGQG RGTGVGGGEV GDGARPGQRT
AGGVGGLHEH ALSQQAPPPE LREPPDSGPG SAPGQGPSVK RTKRDKAESM LRNDSLSSDQ
SESLRPPPPR PYKSKRGQGA GGKRQTSVSS SEEEGGTTPE YSSCEDAEIE SVSERGDWEC
YPHDPTVWHH PVTWQPSKEG DHLIGRITLS KRTAAMPKEA GALLGLKVVG GRVTESGRLG
AFITKVKKGS LADVVGHLRA GDEVLQWNGK LLPGATMKEV YNIILESQAD PQVELVVSRP
IGDIPRIPDT SHPPLESTGS SSFESQKMER PSLNVLSPSS PGMLRDAPQL MPGRLSVKLW
YDKVGHQLIV NVLQAVELSL RPDGRPRSPY VKMYFLPDRS DKSKRRTKTV KKTCEPKWNQ
TFVYSHVHRR DFRNHMLELT VWDQPRSPEE DSIFLGEVLV ELETALLDDK PHWYPLQTHD
VSSIPLPQPS PYLPRRHIDA PGKKLQPDGR GRERQREPTS TLEVPEQQRT PTHHIRSRSV
SPHREEQGRI RSRPPNVPPQ RSLDDELSHG HRSRSPSRYY DAGRGRHQGE GYLDDSEVFT
IHQSMRGKSA ECLHTRRPTR HNNTLPPKMP LLFSSFRKQA NSDLQPSLDR VRSASANCLA
PNNHAPSPET ERGHLQSGGS LSSSVTSSST RRVRQLPQLP PKSSTVEQAL VAEERVRQLQ
MRVHSNRVSA PATSSQQDLD RALKNKRELY KDQRRSSENV SHKSSDSDVS DVSAISRTSS
ASRISSTSYM SIQSERPRGR FSRAMRASGR HMMKSTSISG EIYGMEHADG SQSDTALGSL
GSGIKKRRSS LSQRVVAILP SRRSRSTSQL SQTEASAGKK VGKAGSSSIQ RSVETGMAVE
YPRGGSAMNR QASRESTDGS MNSYSSEGNL IFSGMRLGAD SQFSDFLDGL GPGQLVGRQT
LATPAMGDVQ IGLMDKKGQL EVEVIRARGL TPKPGSKSLP APYVKVYLLD NGTCKAKKKT
KIARKTLEPL YQQHLLFDES PQGKVLQVIV WGDYGRLDHK CFMGVAQILL EELDLSSTVI
GWYKLFPPSS LVDPTLAPLT RLASQTSLDS SGPPPGVRS
//
