ID A0A3P8PWK7_ASTCA Unreviewed; 712 AA.
AC A0A3P8PWK7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Cleavage and polyadenylation specific factor 3 {ECO:0000313|Ensembl:ENSACLP00000021431.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000021431.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000021431.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000021431.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P8PWK7; -.
DR STRING; 8154.ENSACLP00000021431; -.
DR Ensembl; ENSACLT00000021916.1; ENSACLP00000021431.1; ENSACLG00000014484.1.
DR GeneTree; ENSGT00940000155699; -.
DR OMA; CKQHITL; -.
DR Proteomes; UP000265100; Chromosome 15.
DR Bgee; ENSACLG00000014484; Expressed in spleen and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd16292; CPSF3-like_MBL-fold; 1.
DR Gene3D; 3.40.50.10890; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR021718; CPSF73-100_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11203:SF11; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF11718; CPSF73-100_C; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SMART; SM01098; CPSF73-100_C; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 31..217
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT DOMAIN 253..400
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
FT DOMAIN 510..711
FT /note="Pre-mRNA 3'-end-processing endonuclease
FT polyadenylation factor C-term"
FT /evidence="ECO:0000259|SMART:SM01098"
SQ SEQUENCE 712 AA; 80550 MW; C0DFC7564C527834 CRC64;
MAAKRKPDAT VPAEESDQLL IRPLGAGQEV GRSCIILEFK GRKIMLDCGI HPGLEGMDAL
PYIDLIDPAE IDLLLISHFH LDHCGALPWF LQKTSFKGRT FMTHATKAIY RWLLSDYVKV
SNISADDMLY TETDLEDSME KIETINFHEV KEVAGIKFWC YHAGHVLGAA MFMIEIAGVK
LLYTGDFSRQ EDRHLMAAEI PSVKPDILIT ESTYGTHIHE KREEREARFC NTVHDIVNRE
GRCLIPVFAL GRAQELLLIL DEYWQNHPEL HDIPIYYASS LARKCMAVYQ TYINAMNDKI
RKAININNPF VFKHISNLKV SECSPWVVSW LISLYMQYFY MCVFQSMDHF DDIGPSVVMA
SPGMMQSGLS RELFESWCTD RRNGVIIAGY CVEGTLAKHI MTEPDEITTM SGQKLPLKMS
VDYISFSAHT DYQQTSEFIR ALKPPHVILV HGEQNEMARL KAALIREYED NDEVHIEVHN
PRNTEAVTLN FRGEKLAKVM GSLADKKCIQ GQRVSGILVK RNFNYHILSP SDLSNYTDLS
MGMVTQTQAI PYTGPISLLV SQLRNLAGDV EQVEGTEKIT VRIFKSITMV HEASMVLLEW
IANPLNDMYA DAVATVILEV QSNPNAQKFV EGKKESFDMD VFVERLALML HDMFGDDCVN
FKDGKNLSVT VDGVTASVDP ETRLVSCAED ETLREMIEVA VHRLHDALSP AF
//
