ID A0A3P8PWL8_ASTCA Unreviewed; 809 AA.
AC A0A3P8PWL8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSACLP00000021437.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000021437.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000021437.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR AlphaFoldDB; A0A3P8PWL8; -.
DR Ensembl; ENSACLT00000021934.1; ENSACLP00000021437.1; ENSACLG00000013477.1.
DR GeneTree; ENSGT00940000163999; -.
DR Proteomes; UP000265100; Unplaced.
DR Bgee; ENSACLG00000013477; Expressed in spleen.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 6.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 617..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 669..799
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 809 AA; 92333 MW; CC23C6178E74E6C2 CRC64;
MALRSGLETL YKRLVGRDAP GSRSIPQSWD SGVGVTNISV TCAKRHLTAI PDDIPGNAVS
LNLSLNGISN ISKVDLRGLS KLEALYVKNN WILQIDDGTF ADLVELKVLD LGENLLTALT
KNMFQGLSKL ETLSLDNNII SFISPVVFQP LVILRLVDLS NNYLHQISDI DYIVKLPTLQ
HLIITHNNFT LFQSDDLHVN TSNLLTLSLD SDIEWEVSNK TFLRSLTRLH MSETSLSFDV
YRAILQTAYS LQEFQMDNIQ KWIDDGLIDV ACQIPSLRTV DVRNSEIHTI KEHMLQSCSN
LVELNLSFNN IKSMADNALP SMTQLRSLIL QNNELSELPV AVQGLTTLEV YDLSDNVISE
LYCPYFWNLK SLTILDLSHN QISYIFDCVF QNLNNLKSLN LENNKIMSFI DTFKDKLQTL
EFLNLRNIDI MNFIHGDFHS LSSLQYLCID LDKCDSVDEG GFEGLDNLQI LYLLGDNYFY
DHFSGLSNLR YYDISKDVLS GLTSLEYLIT EAYFMGSFEL SVLTSDVFLP IPNLITLDLS
NNKLSETVIQ SLPGLTYLDL SANLLTCECS NYGLIQWIQG SKQTQVVNAH QYTCSFPVSQ
RGKKFLDFGF DSCRIDAALL CFLFSSSLVM LTLLASFIYH FLRSHLTYAY YLFLAFLYDN
KRRKKGIPHS YDAFVSYNVH DEAWVCGELL PELEGQQGWK LCLHHRDFEP GKPIVENITD
AIYRSRKTIC VISPNYLQSE WCSKEIQMAR YGYQLFVLTS NQLSPYYQIR SLVKRSSYLS
WPQAGQHTGI FWQKIRQALE REENPTEHT
//
