ID A0A3P8PXL3_ASTCA Unreviewed; 1165 AA.
AC A0A3P8PXL3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=SEC24 homolog A, COPII coat complex component {ECO:0000313|Ensembl:ENSACLP00000021639.1};
GN Name=SEC24A {ECO:0000313|Ensembl:ENSACLP00000021639.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000021639.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000021639.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000021639.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR AlphaFoldDB; A0A3P8PXL3; -.
DR STRING; 8154.ENSACLP00000021639; -.
DR Ensembl; ENSACLT00000022141.1; ENSACLP00000021639.1; ENSACLG00000014725.1.
DR GeneTree; ENSGT00950000182924; -.
DR OMA; AVECSKQ; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000265100; Chromosome 10.
DR Bgee; ENSACLG00000014725; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 499..535
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 572..811
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 816..900
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 911..1011
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 1038..1111
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..135
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..164
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 126408 MW; 12B085FDE8401D11 CRC64;
MSTAGFNSQN GTGTGQTYAN GPSQNPVALQ QLPGVSYGMT NQPPYNPVQA KAPAPPGPGL
YPAGLYQPIP PVSSYQPGPP PTSYPSSAGQ PLLPRPPMGG HPSHTPPQSA SPSPGPRMPM
PPAQATPPPP SVSSSSYYPN PQQPMTPAWQ YNTPTPPLGP ATSISAPPMG PVANHVNPAA
TLAGPSLPSS ASYSSAAPLP PPPNMSYSTT QPPGPGMPPT SLHGYTQPGV APPPMNPMAP
HTYQGQSNRP AYGPPPTGPT PAGPPPTMKP TSFPTGPPVA NATPPPPKAD AQCGGVVNST
LSPTKPDSQE GDIECPGAVA GNGPQATNSY NHLDNKMAGP TQPGPPGRHL GHYPSLPPGY
QNTSAPHATP PIHPAMQAAT QPYTQAPQPY QQPPGGPGPA QLSPSLAAMS LQSSTPEALR
VVNLLQERNL LPPAPVPAPT PCLTQDLQKL NCSPEVFRST LTSIPQTQSL LNKAKMPLGL
LLHPFKDLSQ LPVVTSSTIV RCRFCRTYIN PFVSFLDQRR WKCNLCYRVN DVPEEFMYNP
VSRSYGEPHK RPEVQNATIE FIAPSEYMLR PPQPAVYLFV LDVSHNAVET GYLNVFCQSL
LDNISSLPGD SRTKVGFITF DSTIHFYNLQ EGLSQPQMLI VSDIEDIFLP TPDSLLVNLN
ESKELVQDLL KSLPNLFEKT METQSALGSA LQAAFKLLSP TGGRMSVFQT QLPNLGVGAL
QSREDPNQRA SAKDIQHLAP ATDFYKKLAL DCSSQQVAVD LFLLSAQYCD LASLGCISRY
SAGSVYYYPS YHHQHNPAQV ERFQKDLKRY LTRKIGFEAV MRIRCTKGLS IHTFHGNFFV
RSTDLLSLPN VNPDAGFAVQ MSIEENLDDM QVVSFQAALL YTSSKGERRI RVHTLCLPVV
NSLSDIFAGA DVQAITGLLA CMAVDRSVTA SLSDARDAMT NAAIDSLMSY RQSVLTIQQP
GLLVPACLRL FPLYILALLK QKAFRTGTST RLDDRVFAML QLKYQPLAYA MLMIHPALYR
VDDLTDEGAL NINERTIPQP RLLQLSVEKL SREGAFLMDA GIVIYLWIGR NCHSNFLTQV
LGVPNYAAVP DNLYLLPELD TAESQRTRAF IGWLRDQRPF FPSLHIIRDE SQLKASFMQN
MIEDRTESAL SYYEFLLHLQ QQISK
//
