ID A0A3P8PZF9_ASTCA Unreviewed; 876 AA.
AC A0A3P8PZF9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Karyopherin subunit beta 1 {ECO:0000313|Ensembl:ENSACLP00000022254.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000022254.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000022254.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000022254.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR AlphaFoldDB; A0A3P8PZF9; -.
DR Ensembl; ENSACLT00000022771.1; ENSACLP00000022254.1; ENSACLG00000015070.1.
DR GeneTree; ENSGT00550000074898; -.
DR OrthoDB; 124901at2759; -.
DR Proteomes; UP000265100; Chromosome 4.
DR Bgee; ENSACLG00000015070; Expressed in spleen and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00185; ARM; 3.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
FT DOMAIN 21..101
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 129..169
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 409..446
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 876 AA; 97381 MW; 82E14684AA36FEF1 CRC64;
MELITILEKT VSPDRNELEA AQKFLEQAAI ENLPTFLVEL SKVLANPGNT QVARVAAGLQ
VKNSLTSKDP DVKAQYQQRW LAIDINARRE IKNYVLQTLG TETYRPSSAS QCVAGIACAE
IPVNQWPELI PQLVANVTDP SSTEHMKEST LEAIGYICQD IDPEQLQENA NQILTAIIQG
MRKEEPSNNV KLAATNALLN SLEFTKANFD KDTERHFIMQ VVCEATQCPD TRVRVAALQN
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
SEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE
DDVVPHVLPF IKENIKHPDW RYRDASVMAF GSILEGPELN QLKPLVIQAM PTLIELMKDP
SVVVRDTTAW TVGRICELLP EAAINEVYLA PLLQCLIEGL GAEPRVASNV CWAFSSLAEA
AYEATDAAED QEEPNTYCLS SSFEIIVQKL LETTDRPDGH QNNLRSAAYE ALMEIVKNSA
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG SDFQKYMEAF KPFLAIGLKN
YAEYQVCLAA VGLVCDLCRA LMSNILPYCD EIMQLLLENL GNENVHRSVK PQILSAFGDI
ALAIGGEFKK YLDIVLDTLQ QASQAQVDKT DYDMVDYLNE LREGCLEAYT GIIQGLKGDQ
ENVHPDVMLV QPRVEFILSF IHHIAEDEDH SDGVVANAAG LIGDLCTAFG KDVMKLVEVR
PLINDLLTEG RRSKTTKTKT LATWATKELR KLKSQA
//
