ID   A0A3P8Q0Z1_ASTCA        Unreviewed;       794 AA.
AC   A0A3P8Q0Z1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|Ensembl:ENSACLP00000022970.1};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000022970.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000022970.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000022970.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8Q0Z1; -.
DR   Ensembl; ENSACLT00000023515.1; ENSACLP00000022970.1; ENSACLG00000015574.1.
DR   GeneTree; ENSGT00940000165438; -.
DR   Proteomes; UP000265100; Chromosome 6.
DR   Bgee; ENSACLG00000015574; Expressed in anal fin and 3 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF372; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1-RELATED; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 2.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          96..215
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          253..549
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          683..744
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          580..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          625..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..603
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   794 AA;  88846 MW;  69AB3040474EE83D CRC64;
     MKDESVRFTS DSSQVSKTVI ESLKIHCHES LHTEGLIYPK SRIKMGKWHL SMDPVQEWGE
     EEEDGAVFGI TLRREPVPTS TMGELPMSFV QYHTVKVRRL KAATLERLVT HLLDPEKRES
     DFIQVFLSTY RAFTSTSTLI ELLFQRNDSV TNLDNSVNAN STLVPVIRLW LEEYSEDFNE
     PPQYQALRTL CVHMQHRLCF RCLVHHAEGL LKRFQEQDCG QPASEHSSES LQQVDEAEMS
     TKNEDKYNFM DLPVREVAEQ LTRLDADLFV KVEPFHCLGC VWSQRDKKEN RNLAPTVRAT
     ISQFNAVTNS VITSLLCTSP HLPSTSSPGL SPSLSSNFLY PSSAPSSPCI LRTSPCHRAR
     VIERWIAVAQ ECRELKNFSS LRAILSALQS NAVYRLKKTW AAVSRESMAT FDHLCETFPD
     ENCVLTNREI LVEDGTHPHS SGMSADKSPR LCSESRQMNY SSGVVPYLGT YLTVLTMLDT
     ALNDTVDGGL INFEKRRREF EILSQIRQLQ ASCSHYRFPV NPRIAAWLQT HTLLTDQESY
     ELSRGLEPPA DLCPSSPNTW SSYLLTRKLA ALRTSVDTPV RKTHADQISV SSSGSSGSDM
     EDLSVPQLSP LRLKLKSFSG SLHNVTEGTS SGSSSPSLSR SSCSSSHPDL TSPSLVLNPD
     PSSSSSSSCS PRALPVYNKQ VSDSCIIRVS VECVSNGNVY KSIVLTSQEH TPQVIQRALE
     KHNMEDFSCS DFGLYQVLKN GKGEYLCFTL QFKQSKHLSA GVTCSEQNEP LSVRTFKLCV
     SSAFSCLQKH KSMF
//