ID A0A3P8Q1D0_ASTCA Unreviewed; 566 AA.
AC A0A3P8Q1D0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Insulin like growth factor 2 mRNA binding protein 2 {ECO:0000313|Ensembl:ENSACLP00000023141.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000023141.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000023141.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000023141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8Q1D0; -.
DR Ensembl; ENSACLT00000023691.1; ENSACLP00000023141.1; ENSACLG00000015512.1.
DR GeneTree; ENSGT00940000154913; -.
DR Proteomes; UP000265100; Chromosome 16.
DR Bgee; ENSACLG00000015512; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd22497; KH-I_IGF2BP2_rpt3; 1.
DR CDD; cd22500; KH-I_IGF2BP2_rpt4; 1.
DR CDD; cd12629; RRM2_IGF2BP2; 1.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF93; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 4.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00322; KH; 4.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 4.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 36..111
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 115..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 61661 MW; A4E9B9878800F6D9 CRC64;
MGTHLLGEVI QSVGKVELHG KVIEVDYSVP KKLRSRKIQI RNIPPHLQWE VLDGLLAQYG
TVENVEQVNT DTETAVVNVT YATKEEAKVA IEKLTGHQFD DYSFKVSYIM DTDAAPPVQA
PRTRRGGRTS RDQGSSQPGP SGGYGSPRPR QHDFPLRMLV PTQFVGAIIG KEGNTIKDVT
KQTQSKVDIH RKENAGAAEK PITIHSTPEG CSAACRMILD IMQKEANETK TTEDIPLKIL
AHNSLVGRLI GKEGRNLKKI EEETGTKITI SSLQDLTIYN PERTITVKGS VDACCKAEME
IMKKLREAYE NDIAAINQQA NLIPGLNLNA LGIFSSGLPV LPPAAGPRSA VPAVAPAGYN
PFLSHSSHLS GLYGVPPASA IPHQHSQQAP EQEVVYLFIP TQAVGALIGK KGQHIKQLAH
FAGASIKIAP AESPDVTERM VIITGTPEAQ FKAQGRIFGK LKEENFFSAK EEVKLETHIK
VPSSAAGRVI GKGGKTVNEL QNLTSAEVIV PRDQTPDEND EVFVKISGHF FASQTAQRKI
REIIQQVKQQ EQKHQQGAAV SPHHSK
//
