ID A0A3P8Q2Z8_ASTCA Unreviewed; 861 AA.
AC A0A3P8Q2Z8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Taste receptor type 1 member 3 {ECO:0000256|ARBA:ARBA00040705};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000023552.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000023552.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000023552.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR AlphaFoldDB; A0A3P8Q2Z8; -.
DR STRING; 8154.ENSACLP00000023552; -.
DR Ensembl; ENSACLT00000024117.1; ENSACLP00000023552.1; ENSACLG00000015997.1.
DR GeneTree; ENSGT00940000160679; -.
DR OMA; MASCLTL; -.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000265100; Chromosome 5.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15290; 7tmC_TAS1R3; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF435; TASTE RECEPTOR TYPE 1 MEMBER 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..861
FT /note="Taste receptor type 1 member 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018260173"
FT TRANSMEM 573..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 572..835
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 861 AA; 95907 MW; 31DD784624AB9A80 CRC64;
MASCLTLLVL CCFFTLSCSE SLPEWVSNIS TNLFSLSGDI MLGGLFPIND VTSSLSDITE
PNQIRCESAN NVVLGLAISM KYAVDEINGN QTLLPGIKLG YEIYDTCRQS SVIINPTLSL
LTEKSSQELP VRCNYTDHEP SIVAVIGPFE SEMVSVIGKL LGFFMLPQIS YGATSDMFSD
KLLYPSFFRT VPSDKWQVDV MIKLIQEFGW NWVAIVGSDE EYGQRGVQMF TKMTVNTSIC
VAYQGLIPVY TDPEPAIETI INDIQTTNVR VVVVFSLAEK AEYFFREVIR SNLTAVWIGS
TSWAIHTRVT SLPNIETVGT IIGFVDKTDT LGLFKDYAME LFKKLSEERT KTSTPTTNPD
SQNNPNNRCT QCWNLSLDNI SIVEAPAVQK SAFSVYAAVY SVAQALHNLL ECNSTACKWG
SGSKIYPWKL LQVLKNTSVN INGTRLDFDN DGNPNIGYNM IQWIWTNSSQ VDFRNVGEYT
EQKLFLNKSL FQWHTKQIPV STCSAKCDRG QVLRVKGFYS CCFDCIDCLA GTYQANEDDT
QCTKCPNGQW SQHRSTNCTD PIFKFFTWDS EDAVIMMLVG VLLLICQGSV GVMFLMHRGT
PLVKASGGPL SFVAVLGLMG ACLSLLLFLG EPRDVVCRLQ LPFTSIFQTV TLSVILSISL
QIICVTEFPE MAASHLHLLR GPVSWLFVLI CCAVQAGLCG WFVQEGPSLS EYVANMTIDF
VEFFLSCPVS SLTGFALMQV FNGAMALASF ICTFIAVEPL HQYNLARDIT FSTLIYCVIW
VIFIPIYVGN NSDNNKIRSI VHVYFSLASN FGLLAAYYFP KCYFLLKKPE LNTAKYFCTF
LEGVPPTQTQ EEQQPKAQEG Q
//
