ID A0A3P8Q392_ASTCA Unreviewed; 736 AA.
AC A0A3P8Q392;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sodium/potassium/calcium exchanger 1 {ECO:0000256|ARBA:ARBA00040585};
DE AltName: Full=Na(+)/K(+)/Ca(2+)-exchange protein 1 {ECO:0000256|ARBA:ARBA00042035};
DE AltName: Full=Retinal rod Na-Ca+K exchanger {ECO:0000256|ARBA:ARBA00042297};
DE AltName: Full=Solute carrier family 24 member 1 {ECO:0000256|ARBA:ARBA00042684};
GN Name=SLC24A1 {ECO:0000313|Ensembl:ENSACLP00000023808.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000023808.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000023808.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000023808.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR AlphaFoldDB; A0A3P8Q392; -.
DR STRING; 8154.ENSACLP00000023808; -.
DR Ensembl; ENSACLT00000024379.1; ENSACLP00000023808.1; ENSACLG00000016209.1.
DR GeneTree; ENSGT01030000234532; -.
DR OMA; WVLLHIV; -.
DR OrthoDB; 22570at2759; -.
DR Proteomes; UP000265100; Chromosome 7.
DR Bgee; ENSACLG00000016209; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF36; SODIUM_POTASSIUM_CALCIUM EXCHANGER 1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 45..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..340
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 575..723
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 371..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..534
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 82145 MW; 7AD69F536ED0FD59 CRC64;
MVFWGENWTP PNFIYAPYFN LAKSNTCCWR KMYCTRRKRL QLSRVLFLLS GVFLCTLYQL
TISTRLYEPL AMPQIAQDSG EGSAEGVEEI ADLGKALTTA YDLEQTEQRN TTYDVHNATT
TSVSTTSTTT ESPLLPTTNR TLVHCIYVAP ELPETPTPAP PTTTVPPAFP GEAPHMKGDY
PEDIFSIEDR RRGWVTLHII GMMYMFVSLA IVCDEFFVPA LGVITNKLAI SDDVAGATFM
AAGGSAPELF TSLIGVFIAH SNVGIGTIVG SAVFNILFVI GMCALFSREI LHLTWWPLFR
DVSFYILGLI FLIIFFLDNV IMWWESMMLV ACYTVYVIFM KFNVQIERAF KTQLHKHKSI
VKVIAVEEPD KTNGNGEDNA PPAPEDKNRL KLKPSLQRGG SSASLHNSTM RNTIFQLMIH
TLDPIGNGKF KEKAETLNSV ARKKSDAKDK SEDGGEKTEQ SKESEPTPAA EEEKKEQPED
KKEDVPAKDD GSGESDDSES DEEDSDDESD ESSEDEDDDE DKDEEEDEKD DEPLSLEWPD
TRRKQATYLF LLPIVFPLWL TVPDVRNPKS RKFFVVTFLG SILWIAIFSY LMVWWAHQVG
ETIGISEEIM GLTMLAAGTS IPDLITSVIV ARKGLGDMAV SSSVGSNIFD ITVGLPVPWL
LYSAIHSFGP VAVSSNGLFC AIVLLFLMLL FVIISIASCN WKMNKVLGFT MFLLYFIFLV
LSVMLEDRII ICPVSI
//
