ID A0A3P8Q3T6_ASTCA Unreviewed; 1246 AA.
AC A0A3P8Q3T6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=VPS10 domain-containing receptor SorCS3-like {ECO:0000313|Ensembl:ENSACLP00000023634.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000023634.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000023634.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000023634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A3P8Q3T6; -.
DR Ensembl; ENSACLT00000024201.1; ENSACLP00000023634.1; ENSACLG00000016080.1.
DR GeneTree; ENSGT01030000234563; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000265100; Chromosome 13.
DR Bgee; ENSACLG00000016080; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF45; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3 ISOFORM X1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1246
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018314292"
FT TRANSMEM 1150..1168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 873..940
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 179..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 140315 MW; 262DC6A38AA4CCF8 CRC64;
MALWSFWGFS LLALVLLCPF HPKFVARAEI SFSTKLDRFY RLDVTPLDAR VARKSAEIKV
SLKIDNNTKV FSAYETNTAG ALKRNHGQQV WNETQSGNEA PIDIKTNYSS GLNIPDKKYD
NIFEDKEGRF KANIMLENTF SAGRKKAKRS VGATYNENVD RSISGEAYSR ERFVQTVQGV
SSARPEYRRS GEEARVSNPR QNEPHLDTST FALSGDSAHN QAMVHWSGHN SSVILILTKL
YDFNLGGVTE SSLWRSTDYG STYTKLNDKV GSRTVLSYLY VCPTNKQKIM VLSDPEVESA
VLISSDEGAS FEKHPINFNI LSLLFHPAQE NWILAYSHDS KLYSSMDFGR KWQLVHDNVM
PGRFYWAVMG LDRESDVVHI ETRIGKGRAQ YVKCRAQRCT EGNRQYLFPG HVDTNSLVVQ
DEYVFTQVTK SGRASYFVSY MRESFKRMKL PKYCLPKDMH IISTDEKQVF AAVQEWNQNN
TYSLYISDSP GVYFILSLEN LRTSRGPAGN LLVDFYKVEG INGMYLANKL VDNYIKTFIT
YNKGQTWSLL PAPATDVAGN NLHCILPFCS LHLQLEMSEN PYTSGPITSK KSVPGIIVAT
GNIGTQLSSA NLGMFITSDA GNSWRQIFDE EYNVWFLDNG GALLAVLQAA APIRHLWISL
DEGKKWDRHS FSLAPLYVDG VLMEPESDNH IITFFGHFSH RSEWQLIKID YKGLFSRRCM
DGDYQTWYLH NKGELCVMGE KQIYMKRRPG NRCMLAQDYS RIYSSEPCPC TAYDFECDYG
WERQADGNCS PAFWFNPNGA AKSCSTSQSF LNSTGYRKVL SNNCKEAGRN VYSPRRQPCH
PRAPRGLQLS TSQGELSSPV GSNVTFMVSL NEGDSLRTSI QLDFGDGIKI TYSNLSRADD
GIKHIYKTTG IYRVTATAEN SQGSDSSTLF LHITSPLERV YLSAPIVAVR GKEANLTAVV
WPSHTRTLTF FWWFDNSSEP IITLEGSISH TFQSEGKSKV TVQVASGSTV MQDSKVTTVK
EFFRSLLLSF SPALDEHNPD IPEWREDIGR VVRTALSQVS GIHEDQLLVS LYPGLPTTAE
LFILPDEQTS TEHKSGSEAA LEMISNIFVT ALNQGLIQFE LKADIRIIVY MTQQTLAPLV
DSNSLPSGSA MLMLLIVVFV GLAAFFIYKF KRKIPWVHVQ TEDSHEKDPE VISTVGQNDT
MSKVKLSEFP SQKELMEKEL EARNIGGIGR NMERIVTREF PNCTNV
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