ID   A0A3P8Q5A9_ASTCA        Unreviewed;      1128 AA.
AC   A0A3P8Q5A9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE            EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000024357.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000024357.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000024357.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC       HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR   AlphaFoldDB; A0A3P8Q5A9; -.
DR   STRING; 8154.ENSACLP00000024357; -.
DR   Ensembl; ENSACLT00000024940.1; ENSACLP00000024357.1; ENSACLG00000016581.1.
DR   GeneTree; ENSGT01100000263500; -.
DR   OMA; QHFHEDP; -.
DR   Proteomes; UP000265100; Chromosome 11.
DR   Bgee; ENSACLG00000016581; Expressed in zone of skin and 2 other cell types or tissues.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.10.20.370; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
FT   DOMAIN          148..327
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          709..867
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
SQ   SEQUENCE   1128 AA;  126947 MW;  C93EABB85073DE1D CRC64;
     MGKRVYQRFV IVQDLSSPFV LGMDFMTRTS LTIHVPTRTV IMDDNPPCLD ELCENGFVEA
     DLECGTMTLQ NTPQLHDKAG EANLDSEERE ELLELLNSFG DLFDGHLGRT SLAEHVIVTG
     DAKPVNLPPY RTSPAKKQII EEQVEKMLQD NIIEPASGPW AAPVVIVNKP PREPRFCVDF
     RGLNQLTVKD SYPLPRVDES LDFLSRGKFL TTLDLARGYW QVPIAEEAKP KTAFITHCGL
     FQFRVLPFGL CNAPATFQRL MNNVLAGLIY KSCAVYLDDI VVASPTFEQH LLDLKEVLGR
     LQSAGLSLKL SKCQFCLSEL TFLGYRVTPA GIHPDPDKVR AVTDFRVPTT TKQVRQFLGL
     TGYYRRFVQD YARHAEPLFA LTKKDVQFHW DDECQAAVDF LKHSITSAPV LRFPDFSRPF
     FIHTDACDAG LGAALMQKDE DDKDVAVAFA SRAMHKSEKP YSTPEKECLA VIWALEHFRP
     YVEGLHVTIY TDHSSLKWLM SRPNPSGRLA RWSLRLQDFD FSIIHKPGER NKVPDALSRN
     PLPDVDAPID LLPPYAVIGS MDLRALPSVI VLDRLHVRQL QLEDPVTGPL LNQLETDQQT
     GENNQDLEQY IVHDSLLYFL DPKTKCGLHP LKQLKLFAPT ALRGYLLKYY HDHPTAGHLG
     IAKTLARLRL RFFWPHMNSD VKKYVVSCRL CQTTKPSQRK TAGLMVPIQP QRPWEYAGVD
     YVGPLPRTQR GNAYILVFVD YFSKWVEVSA VREATAQVAA NKFITDIFAR HGSPSHLISD
     RGTPFVSELF EHVLLTLGTE HRLTTAYHPQ TNATERVNRT LKTAIRAYVG DKHTSWDKYL
     PQICFALRTA PHESTGLSPS MMLYGRELDT PLDLVTQPSW EGLSDPETSH SDNLRASLRD
     AHEHARLVLG ESHERQKRYY DLRRRTVSYE VGDLVRVKSH PKSDASSNFS AKLAPLYTGP
     YRISKRMSDV NYSLTTVDTG ERVGVFHVAN MQPFHTWDSA LSSQRAKLNA TAALDLSVPD
     SSLPPALSVP GRIDCDAVDT TPAVFSNASA ETDFDYADAA PLVVDQNSFQ ETADVALETE
     VNSSPPAADG CAVRGSYDLR PRRVPRVTAD WSVNRWTNPF HTDRFDIK
//