ID   A0A3P8Q897_ASTCA        Unreviewed;       588 AA.
AC   A0A3P8Q897;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000025402.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000025402.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000025402.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8Q897; -.
DR   STRING; 8154.ENSACLP00000025402; -.
DR   Ensembl; ENSACLT00000026010.1; ENSACLP00000025402.1; ENSACLG00000017283.1.
DR   GeneTree; ENSGT01100000263487; -.
DR   OMA; MDESALC; -.
DR   Proteomes; UP000265100; Chromosome 2.
DR   Bgee; ENSACLG00000017283; Expressed in spleen and 3 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM00368; LRR_RI; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        534..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          23..175
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|Pfam:PF05729"
FT   DOMAIN          259..319
FT                   /note="NOD2 winged helix"
FT                   /evidence="ECO:0000259|Pfam:PF17779"
FT   DOMAIN          321..422
FT                   /note="NACHT LRR and PYD"
FT                   /evidence="ECO:0000259|Pfam:PF17776"
SQ   SEQUENCE   588 AA;  67073 MW;  95FCA8B0FF6F5B06 CRC64;
     SLSFFPKELP VLVTLGVVKI KYLAVFTLDW AEEQANQDIQ FTFPFTFREL NVLKEKKFSL
     VGLVHHFFTE TKKAGIYWFE HFQVVFILDG LDECRLPLDF HRSETLTDIT QSASVGVLLT
     NLIRGKLLPS AHVWITTRPA AASQIPPEFV QMVTEVRGFT DEQKEEYFRK RFRDEEQASR
     IISHIKSSRS LHIMCHIPVF CWITATVLEN MLKTREGGIL PKTLTEMYIY FLVVQSKVRK
     IKYDGGAETD CHWGPESKKM IESLGKLAFD QLEKGNLIFY ESDLTECGID IRAASVCSGV
     FTQIFKEEKG LYQNPVFCFI HLSVQEFLAA LHVHLAFINS GVSVLPEEQT ASQTSETPKN
     KIVKTDFYQR AVDNALQKSS SETNQKTVQY IKMKISENLS AEKSINLFHC LNELNDRSLV
     EEIQQSLSSR TLSVDKLSTA QWSALVFILL SSENDLDEFV LKKYSASEQA LLRLLPVIKI
     TEDGCRYLVS ALNSNLTHLK ELDLSYNNPG DSGVQLLSDA LEHSLRKLET LRSVLMIIFN
     FSLFGIFVSF LRIFSVCKKL CSLHIQFNFI YIAPNHNSSC LKALYIVQ
//