ID A0A3P8Q8D4_ASTCA Unreviewed; 1445 AA.
AC A0A3P8Q8D4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000025159.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000025159.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000025159.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR STRING; 8154.ENSACLP00000025159; -.
DR Ensembl; ENSACLT00000025765.1; ENSACLP00000025159.1; ENSACLG00000017120.1.
DR GeneTree; ENSGT00940000160188; -.
DR OMA; FLESECC; -.
DR OrthoDB; 2663363at2759; -.
DR Proteomes; UP000265100; Chromosome 19.
DR Bgee; ENSACLG00000017120; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
FT REPEAT 524..556
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 557..589
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 593..625
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 462..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..499
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..967
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1445 AA; 158568 MW; 4CED4B959A47E304 CRC64;
MSVSREIKQL QKAKSKAQSS NNLKEEANIC NQLGELLSRS GDYQAAIREH QQELALSEVL
IDVIGRAVAN RKIGECFAEL GNIEAALKHQ RLHLDLARSV RDHAEEQRAL ATIGRTYLFR
YETDQSRKSL EEAEEAFRKS LGIVDDRLEG TVPQREINEM KARLFLNLGL VCDHLGEHKR
CSEFIRRSVF IAEKSQLLED LYRANFNLGN IYFRNGQRSN SVRCLEQAKE CARKIKDKFS
ESECFHCIGK VQLSLGDFVA ARRSLKKAVL LGSQQPLDRQ TVKIAFKYAD RGCKLEEELG
EDQGKKPSSH QAVELAEQLG DLCCKVGCYS KALEAYQAQL KGAEALGKPA RELAVIHVSL
AATYADLKQH SKSVEHYRKE LALRQGSSTE ECSTWLNIAA AQEESGCALE DVERSYNTAL
RCAQESGQAR LQKRVLRLWL ASQRRSGSSD ADNTEARLQE LCASEGWNPD GSDGEEEEEE
EMENSEPLDD SDVILSDSDD DLEGYDKMVS GRRKTGRWNK RNEKGETSLH RACIDGNLKQ
VQYLVEQGHP VNPRDYCGWT PLHEACNHGH YDIVALLLEH GANVNDPGGP LCEGVTPLHD
AVACGNLEVT RLLVERGACV TLRNSKGETA LDTLRQWQRT YSRELDHETR QKCIATERLL
RKALAGGVPA APAPAKPFDA LQDSQLFDAE SSEPLSSTGG GSFSRQDWPR SRSSEVKASG
ASRKQRQTNG STQRNRARGT EAAVLYGINS SSSDDSEPDT PVSPLRPVRP RQGFPAAQSQ
KEPPANKEAA SVPTSGQEGI RQASTPSVFA REEYHSAIRG LGSAKTLLQG LSQPQLSSTP
AVSSSTKSAL VPEDEYLADD WLEDDLVEIQ PKKKRRLRME QNGPRVEETA SSSAARSQNK
HLNLDTTCRG SAVSSLSSRG LSQRKNSLGK PHQVKMTQIP GVARLGRREV NRSHSPTVTE
DDDSRSDTPP PPLLIHAQPP TQTLAAPMPT SLPPPIRMRV RVQEDVFLIP VPQSEANSCS
VSWLCEQAAQ RYYQKCGLLP RLSLQKEGAL LSPQDQLLAV LHTNEEVLAE VCSWDLPPLP
ERYKKACQSL AVDENKRVSR LCEVQDRGFS VSVCGLGLAA SSLSPLLRAL KLQASLTELR
ISGNRMSDDL LPELIATTLT MPRLQLLDIS ANCITGDGLE KAVNALKGQS APAFPCLEEL
DLSMNPLGDG VSESLSCLLS CCPVLAKLSL QACGLTARFL QQHRLLLASA LTGTGHLKAV
CLSHNPLGST GFELVLKTLP LHCLTHVDLS AVCRGPADYP ALEHLAKVLS QDECSLTHLS
LAANGLTDSS VATLARCLSS CPTLVSLNLS GNPSVTSVGL HNILASVREA RRPLTLLNLE
GCQVSGPWES QDLDSLSELV QDIRLCSQTL NKLDRQTLKQ SWDRTQSHGH FLDRNSKCLL
SATST
//
