ID A0A3P8QA10_ASTCA Unreviewed; 790 AA.
AC A0A3P8QA10;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Transcription factor E2F7 {ECO:0000256|ARBA:ARBA00039675};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000026221.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000026221.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000026221.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR AlphaFoldDB; A0A3P8QA10; -.
DR STRING; 8154.ENSACLP00000026221; -.
DR Ensembl; ENSACLT00000026838.1; ENSACLP00000026221.1; ENSACLG00000017822.1.
DR GeneTree; ENSGT00940000157713; -.
DR OMA; VEDSCQF; -.
DR Proteomes; UP000265100; Chromosome 17.
DR Bgee; ENSACLG00000017822; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF25; TRANSCRIPTION FACTOR E2F7; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 152..221
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 274..359
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..141
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 85615 MW; E6AD9427E3133186 CRC64;
MEVQCLALKD LSSPRKSSTV VPEEEDGARG EQKENMCAEK RKSTPLKSAE STLPTLLINR
KGAPSELAHI TPIKHTSLTE PWTPTANLKM LISAASPDIR DREMKKVLFR PIENDKDQPA
SPDNVVEDPE VEDSCQFEAA DEEDDAEKKP SRKQKSLGLL CQKFLALYPD YPPLHSPIWI
SLDEVAANLG VERRRIYDIV NVLESLTIVG RIAKNSYTWY GRQRLEATLE ELQCEGRQQG
YHLQMEQANE ARETGPGRED DGGEGDAGSA GSNRKDKSLR IMSQKFVMLF LVSKTQTVTL
DAAAKVLIEE SQDSSSHSKY KTKVRRLYDI ANVLTSLSLI KKVHVREERG RKPAFKWLGP
VEFSSSVNAG NTLNVAAIAS SESAQPGQEL RKAKMARHAS FSITPTSVAV QRQVSSAPSS
PRREVTALQN QPVDYSSRTT SNSAACQLQF GSNADNRPGT PPQTRLMHNS STALSPSSTL
LAPLPHPEHL FVASPSSHCL AYLPSLSQPS VVMLYRPPET PNQMLEGHTS PRLEATKRKK
EEREEEEMVL KKKGNSALEK CEKTRAEACR ETAECSQAGA AAAGLCREQV IGESGGGNTS
SEHAQPSHYL YVPNNAGLNG LNFLLSAGQP AASLALPPSS VPTLALPYVL VPSAALSHYP
LVAGSLQQQG SDAHTKLSFG LPAMMSPAHF MVGGAPYSVV PVPPPSTPEQ SGLYRSSAGT
PHSPSRPRQT ISINTPEPLT PHTPKETPAS SSKAFFQTPG TLGSVVSAAP AVRKRGSAQR
RLDIGHHPTS
//
