ID A0A3P8QAR1_ASTCA Unreviewed; 265 AA.
AC A0A3P8QAR1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Vascular endothelial growth factor B {ECO:0000313|Ensembl:ENSACLP00000026446.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000026446.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000026446.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000026446.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8QAR1; -.
DR STRING; 8154.ENSACLP00000026446; -.
DR Ensembl; ENSACLT00000027065.1; ENSACLP00000026446.1; ENSACLG00000017988.1.
DR GeneTree; ENSGT00940000166453; -.
DR OMA; KCEATRT; -.
DR OrthoDB; 5358226at2759; -.
DR Proteomes; UP000265100; Chromosome 2.
DR Bgee; ENSACLG00000017988; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.10.160.10; Vascular endothelial growth factor, heparin-binding domain; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR036841; VEGF_C_sf.
DR PANTHER; PTHR12025:SF14; SNAKE VENOM VASCULAR ENDOTHELIAL GROWTH FACTOR TOXIN VR-1'-LIKE ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF57593; Heparin-binding domain from vascular endothelial growth factor; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..265
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017995046"
FT DOMAIN 43..138
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 144..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..164
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 29893 MW; C15F9601A6343BF7 CRC64;
MGIMLQVILG MFQFLLLTRI PTSHAKLAHW RPADSPKSRE GREVRRWLEV YSRSGCEPRD
TLVEVWREFP DETHSLFIPS CVSVRRCGGC CADEAFECVP TLTHTVTMEL MRTSFMKHEL
TELPFIEHSQ CDCRLKEHLQ PTPTSRAFLK PARKGKKKER GRKSKQKITG ATRAATHAPP
VPSATSFPSP PSLPPTNISP STISFPSPSP SPSPSPTTRC RPCRRRKWAL DSTTCQCRCT
VTAETCSQKG RKLNPRRCKC EAMRT
//
