ID   A0A3P8QAV1_ASTCA        Unreviewed;       856 AA.
AC   A0A3P8QAV1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000026458.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000026458.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000026458.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8QAV1; -.
DR   Ensembl; ENSACLT00000027079.1; ENSACLP00000026458.1; ENSACLG00000018002.1.
DR   GeneTree; ENSGT01100000263558; -.
DR   OMA; CNDIDMM; -.
DR   Proteomes; UP000265100; Chromosome 17.
DR   Bgee; ENSACLG00000018002; Expressed in brain and 6 other cell types or tissues.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
FT   DOMAIN          404..672
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   856 AA;  99888 MW;  01CF040EFEB958DD CRC64;
     MTMVIDNVLE CITVEICKEK SKNVIISCIY RAPGSSIETF KDWIEETFIE IARKKVFICG
     DFNIDLLNPN KHKTTEEFIN TMHCMNLFPK ITRPTRITSH CATLIDNIFA NDIENKTVSG
     LLINDISDHL PIFTIYDRNY KINKMDSIKE YRRVRTEERM NAFKKDLLKE NWGEVYQEQD
     VNSAYNKFLR IFTLLYNTNC PIKQYSRKQK YMDCPWITKG LQNACIKKNA LYREFLRTRT
     KDAEIRYKRY KNRLTNILRF SKKEYYKKQL DINRNNNKRL WEILNSVIKC GTGQKNYPKY
     FICNDHEEYN MDVVANSLNE FFVTAGPNLA RTITHPGKAQ EKPDTLIDRN PYSMFLTAVD
     ENEVLEIVKK CKNHKSLDCN DIDMIVVKRV IEAIIKPFTY ICNLSFQTGR FPDRMKIAKV
     IPLYKSGNKH HFTNYRPVSL LPQFSKVLEK LFKNRLEKFI DKHKLLTESQ YGFRSSRSTS
     SALLDSIEYI TNSIDKKQYV AGLFIDLTKA FDTIDHDILI RKLERYGVRG VVLDWVRSYL
     SDRKQFVKIN GGCSLCMDIA CGVPQGSVLG PKFFNLYIND ICKVSKVLKM VLFADDTNIF
     CSGDDLQNLL EDMTNEISKV KFWLDKNKLS LNLNKSKLML FGNSSLNTNA KIQINGVDIE
     RVSENKFLGV IIDEKLNWRA HVRYIHSKVS RSIAVLNKAK QVFDRTSLHI LYCSLVSPYL
     SYCAEVWGNN YKTTLHSLFT LQKKAIRIIH NAGYREHTNS LFLQSEILKI DDIVKFQTAQ
     ILFKAKNKEL PGNIQSMFFL KEGSYNLRGF CNFKTMKVRT TRKGFCVSVQ GVKLWNKLNM
     ELKQCPNIKL FKKSYK
//