ID A0A3P8QCX3_ASTCA Unreviewed; 1985 AA.
AC A0A3P8QCX3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dedicator of cytokinesis 6 {ECO:0000313|Ensembl:ENSACLP00000026799.1};
GN Name=DOCK6 {ECO:0000313|Ensembl:ENSACLP00000026799.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000026799.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000026799.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000026799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 8154.ENSACLP00000026799; -.
DR Ensembl; ENSACLT00000027428.1; ENSACLP00000026799.1; ENSACLG00000018104.1.
DR GeneTree; ENSGT00940000159313; -.
DR OMA; TFYHLGC; -.
DR Proteomes; UP000265100; Chromosome 4.
DR Bgee; ENSACLG00000018104; Expressed in anal fin and 8 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF65; DEDICATOR OF CYTOKINESIS PROTEIN 6; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1985
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018272889"
FT DOMAIN 538..704
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1530..1961
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 153..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1985 AA; 225733 MW; B7A128D67EAE77A3 CRC64;
HPCFISNLQS FLLFRTVAAE VRKQVSRDYG SPQLSKKRGG LPLTEVVEPV DFEEYVSSHA
PGVEPGPLKQ LMEFPSDDLE LLHLDKDCNT LEPPLSLDSR VRDALAVYTD DWLVIQRKYQ
LYSTTYTPHN SERQRERQRG LVKQTFELDE AAAAERQEDQ DDAKRRSVSI DETPRGSWAS
SIFDLKNSSP DALLPTVLEQ TAAEDMDHRN TEARQQGRHN DLLGLFPPPD EDEAVERCSL
PEVPKEHCGQ RIMVKCLSLK FEIEIEPIFG TLALYDIKEK KKISENFYFD LNSDQMKGLL
KPHTPHVAIS TLARSAIFSI TYPSPDIFLV IKLEKVLQQG DISECCEPYM VMKESDSSKH
KEKLEKLRLQ AEQSCTRLGC FRMPFAWTAI HLLNIVSSVG GLDRSDPDSD SGHGTWNERK
KKGFERMSIG DDMCNFATFR PATLTVTNFF KQEGDRLSDE DLYKYLADMR RPSSVLRRLR
PVTAQLKIDI SPAPDLPHYC LSPELLHVKP YPDLRVRPTK EVLEFPARQV YTPHTTYRNL
LYVYPQSLNF SSRQGSVRNI AVKVQFMAGE DPSQALAVIF GKSSCAEFMK EAYSPVIYHN
KSPEFYEEMK MKIPANLTDN HHLLFTFYHI SCQPKQNTPL ETPVGYTWIP LMQHGRLRTG
SFSLPVSVEK PPASYSVLTP DVSLPGMKWV DNHKGVFNVE VKAASSVHTQ DPHLDKFFTL
VYVLEEYSFP FRLKDVIITE ANMEGELKAS MAALRGAVLD TCVRFLHQLL NKLIQLIVYP
PVIAGQIVNL GRAAFEAMAL LVNQIHKNLE GNQDQHGRNN LLASYIHYCF RLPTAEPTLP
PNGESPGLTY ATLSRATARP SSLHLSRSKS ISNSNPDLAS TPVSPDEEVQ RIMGSKLLHE
ELALQWVVST STVREAALQQ AWLFFQLMTK SMAHHLFLTS KLDVPRRQRF PDRFVDDIAA
LVCAISADIA SRYHKDVELV ERLNSSLAFF LSDLLSLMDR GFVFNLIRSY YKQVPIALFP
IFLHFSIILC HLNYVSLCPQ SSAFSSMVQD QGVATMFELS VPFRQQHFLS GLLLSELSLI
LDPDGEGVFF LHKKAISAVH SLLCSHDADP RYRDPQVRAH MAQLYLPLIP IVMETLHQLY
DFSGQQNNMN SGSTISQSVA MAIAGSPLQH AKANPFALPT AGRQSSSLSA ECSRTLLVCF
LWVLKNADAA LLERWVSDLS VLQINRLLDL LHLCVSCFEY KGKKTLERIN SLTFKKSQDM
KARLEEAILG TIGARQEMVR RHRERSPYGS QENVRWKKNV THWRTNADRV DKTKAEVEQE
SVVDGNLATE ASLIVLDTLE IIVKTVVASE LKESVLGGVL RVLLHSMAGN QSALFLQHCF
NTQRALVFKF PEMLFEEDTE LCADLCLRLL RHCSSSVGSV RSHASASLYL LMRQNFEIGN
NFARVKMQVT MSLSSLVGTS QNFNEEHLRR SLKTILTYAE EDLELRDTPF PEQVQDLVFN
LHMILTDTVK MKEHQHDPEM LIDLMYRIAK GYQNSPDLRL TWLQNMAGKH SERGNHAEAA
HCLVHSAALV AEYLNMLEDC RYLPIGCVTF QNISSNVLEE SAVSDDVLSP EEEGICAGKY
FSESGLVGLL EQAAASFNMA GMYEAINEVY KILLPIHEAN RDFKKLATVH GKLQDAFNKV
YNQRMFGTYF RVGFYGCRFG DLDEQEFVYK EPSITKLAEI SHRLEEFYSE KFGDEVVEII
KDSNPVDKNK LDPNKAYLQI TYVEPYFDTY ELKERITYFD KNYNLRTFMY CTPFTLDGRA
HGDLHEQYKR KTILTTSHAF PYIKTRINVI HKEEIILVPI EVAIEDMQKK TQELAFATNQ
DPADSKMLQM VLQGCVGTTV NQGPLEVAQV FLADIPDDPK LFRHHNKLRL CFKDFAKRCE
DALRKNKALI GPDQKEYHRE LERNYHKLKE ALGPLINRKI PQLYRTLPAP TLNSYSRSSF
RKVDC
//
