ID A0A3P8QD83_ASTCA Unreviewed; 813 AA.
AC A0A3P8QD83;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=BRCA1-associated RING domain protein 1-like {ECO:0000313|Ensembl:ENSACLP00000027485.1};
GN Name=BARD1 {ECO:0000313|Ensembl:ENSACLP00000027485.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000027485.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000027485.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000027485.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8QD83; -.
DR Ensembl; ENSACLT00000028130.1; ENSACLP00000027485.1; ENSACLG00000018628.1.
DR GeneTree; ENSGT00940000156532; -.
DR OMA; KKSIKMW; -.
DR OrthoDB; 2478587at2759; -.
DR Proteomes; UP000265100; Chromosome 16.
DR Bgee; ENSACLG00000018628; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd17720; BRCT_Bard1_rpt2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039503; BARD1_Znf-RING.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR PANTHER; PTHR24171:SF8; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF14835; zf-RING_6; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 450..482
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 483..515
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 516..548
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 602..684
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 698..811
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 173..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 88869 MW; EF715BB7D0596CF7 CRC64;
MDEHSSVQTV DWKKTKEAAA NFRRLLLCSK CSDLMKEPVC LGLCEHMLCR SCAGPRAGDG
CVVCHSPAWV KDIQINRQLS SIIELFCGLE SLLTPIKNPD SSVAEIQPDG PVPKNNKKNF
KIWFSPRSRK VRCTVEKAAE ITVPDNRSPG ETSAAQQDTL TAQCQDLSVF NFTSSSQDSG
SSSSQSCNGE TKNDRKKRST KKNATSRNVP VQGATRTTRK QTKQNLKKKR LEAINQQWGI
SEEAHLSENE QVCADGARRS SKRVSFLSPV VTSDGPQPEM AQRSTDKLSP ARSTVRESLS
QGSETVLNCQ TELVQPLPES AFQHDQLSAD VPKPNDNPKN HKNVSPSEHS SKRSRTEDRN
STLDNTPKRP RPSPGRRGRK SLSPISPVVL NPPSLTTPKS TKKSRKEGRD SPSVQASPST
ESYRRSSCFN GASVGRSSPG SPAVMKRNHK GETLLHLAAI KGDVEAVKDL LDQGADPNLK
DNAGWTPLHE ACNLGHLAVV ELLVSMGALL NTPGYENDSP LHDAVRNGHS SIVKLLLQLG
ASQNVLNLYG KRPADYAASL EMLEIFQEAS EGTQYANARI SHSPSASLSV VNDCVRREQT
IVLLSSKLSP AERHQLVKLG QLLGGRMADT FSGSVSHIVV PEGQMPTTYS TLMGLLAGCW
IVRYKWVEAC LQAGKWVPEA EHEAGEGPQR SRINRCSLLP PLFDGCFFFL LGSFKTPTKD
ELTKLLREGG AQLLNRQPKP DSDVTQTVNA TAYHALPGSD QALCTHYIIY DPQAPHKPSV
VRRGKVWSAP TTWVINCITA FSLLPVPDPE LLV
//
