ID A0A3P8QDG6_ASTCA Unreviewed; 697 AA.
AC A0A3P8QDG6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 4 {ECO:0000313|Ensembl:ENSACLP00000027157.1};
GN Name=KCNQ4 {ECO:0000313|Ensembl:ENSACLP00000027157.1};
OS Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000027157.1, ECO:0000313|Proteomes:UP000265100};
RN [1] {ECO:0000313|Ensembl:ENSACLP00000027157.1, ECO:0000313|Proteomes:UP000265100}
RP NUCLEOTIDE SEQUENCE.
RA Datahose.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACLP00000027157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8QDG6; -.
DR STRING; 8154.ENSACLP00000027157; -.
DR Ensembl; ENSACLT00000027792.1; ENSACLP00000027157.1; ENSACLG00000018427.1.
DR GeneTree; ENSGT00940000159209; -.
DR OMA; YATCLHM; -.
DR Proteomes; UP000265100; Chromosome 22.
DR Bgee; ENSACLG00000018427; Expressed in spleen and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF7; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01461; KCNQ2CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..320
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 463..652
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 29..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 78900 MW; 61B2094D3F86C923 CRC64;
LLSSPPSQML APPAPNDERR VEFVALTAVQ TERSEPSTPE RGHPSHRTGL LGTPLPGPPG
PRANMSASSK RYRKLQNCLY NVLERPRGWA FIYHAFIFLL VFSCLVLSVF STIPEHQKAA
NQGLFILEFV MIVVFGLEYF IRVWAAGCCC RYRGWKGRLK FARKPFCVID FIVFVASLGV
IAAGTQGNIF ATSALRSMRF LQILRMVRMD RRGGTWKLLG SVVYAHSKEL ITAWYIGFLV
LIFASFLVYL AEKDINSDFN TYADSLWWGT ITLTTIGYGD KTPHTWQGRL LAAGFALLGV
SFFALPAGIL GSGFALKVQE QHRQKHFEKR RMPAANLIQA AWRLYSTDAK HSYLTATWYF
YDSMLPSFRE LTLLFSHLQR QRNTKKVLHN SYHTLLSGLR PYSSPYLSGD RYATCLHMFN
SFYFAVSGKI GFRDRIRMNN SRSSQTIRNK ASPLSPSSGV RRSPSQENVP EATSPGKVQK
SWSFNDRTRF RTSLRLKPLT HRCSALIEGL GEDSVEDKPY CDVTMEEVIP AVKTLIRAVR
ILKFLVAKRK FKETLRPYDV KDVIEQYSAG HLDMLGRIKS LQTRVDQIIG RGAVQPDKKT
RPEKGEKTQP ELDSLDELSM MGRVVKVEKQ VQSIENKLDL LLNFYSQCLK KGSSNFTLSS
LLDPDLTSDY HSPTDQRDLF PSANTLNISQ SESGNLE
//