ID   A0A3P8QDL8_ASTCA        Unreviewed;      1015 AA.
AC   A0A3P8QDL8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000027625.1, ECO:0000313|Proteomes:UP000265100};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000027625.1, ECO:0000313|Proteomes:UP000265100}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000027625.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8QDL8; -.
DR   Ensembl; ENSACLT00000028272.1; ENSACLP00000027625.1; ENSACLG00000018778.1.
DR   GeneTree; ENSGT01100000263558; -.
DR   OMA; WRTEGNT; -.
DR   Proteomes; UP000265100; Chromosome 19.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR46670; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46670:SF3; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
FT   DOMAIN          564..832
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   1015 AA;  118570 MW;  CC6FC35D8FA6BF2A CRC64;
     MTHTGRKNSD TSGRISCISQ TVAEYDQLEL KTFNYMDHNT HDLEYEIDPD NNFFSSNNNN
     CCYYTNKDYN QRIKTENKLS IIHFNCRSLY ANFSHIKEYL NQFSHPFSVI ALSETWINME
     KGTDFELEGY EFTFITRRNK GGGGVALYVD KSLKFNVVEK MTMVIDNVLE CITVEICKEK
     SKNVIISCIY RAPGSSIETF KDWIEETFIE IARKKVFICG DFNIDFLNPN KHKTTEEFIN
     TMHCMNLFPK ITRPTRITSH CATLIDNIFA NDIENKTVSG LLINDISDHL PIFTIYDRNY
     KINKMDSKKE YRQVRTEERM NAFKKDLLKE NWGEVYQKQD VNSAYNKFLR IFTLLYNTNC
     PIKQYSRKQK YMDCPWITKG LQNACIKKNA LYREFLRTRT KDAEIRYKRY KNRLTNILRF
     SKKEYYKKQL DINRNNNKRL WEILNSVIKC GTGQKNYPKY FICNDHEEYN MDVVANSLNE
     FFVTAGPNLA RTITHPGKAQ EKPDTLIDRN PYSMFLTAVD ENEVLEIVKK CKNHKSLDCN
     DIDMIVVKRV IEGIIKPFTY ICNLSFQTGR FPDRMKIAKV IPLYKSGNKH HFTNYRPVSL
     LPQFSKVLEK LFKNRLEKFI DKHKLLTESQ YGFRSSRSTS SALLDSIEYI TNSIDKKQYV
     AGLFIDLTKA FDTIDHDILI RKLERYGVRG VVLDWVRSYL SDRKQFVKIN GGCSLCMDIA
     CGVPQGSVLG PKFFNLYIND ICKVSKVLKM VLFADDTNIF CSGDDLQNLL EDMTNEISKV
     KFWLDKNKLS LNLNKSKLML FGNSSLNTNA KIQINGVDIE RVSENKFLGV IIDEKLNWRA
     HVRYIHSKVS RSIAVLNKAK QVFDRTSLHI LYCSLVSPYL SYCAEVWGNN YKTTLHSLFT
     LQKKAIRIIH NAGYREHTNS LFLQSEILKI DDIVKFQTAQ ILFKAKNKEL PGNIQSMFFL
     KEGSYNLRVF CNFKTMKVTY YKKRLLCFCS RSETMEQSEY GIKAMSKHKT VQKEL
//